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P3700000

Propylthiouracil

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

6-Propyl-2-Thiouracil, 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinon, 4-Hydroxy-2-mercapto-6-propyl-pyrimidin

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About This Item

Empirische Formel (Hill-System):
C7H10N2OS
CAS-Nummer:
51-52-5
Molekulargewicht:
170.23
Beilstein:
130039
MDL-Nummer:
MFCD00006041
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329820187
NACRES:
NA.24

Qualität

pharmaceutical primary standard

Beschreibung

enzyme inhibitor

API-Familie

propylthiouracil

Hersteller/Markenname

EDQM

mp (Schmelzpunkt)

218-220 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

CCCC1=CC(=O)NC(=S)N1

InChI

1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)

InChIKey

KNAHARQHSZJURB-UHFFFAOYSA-N

Angaben zum Gen

human ... DIO1(1733) , TPO(7173)

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Propylthiouracil EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

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Produkt-Nr.
Beschreibung
Preisangaben

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Warning

H-Sätze

H302,H351

Gefahreneinstufungen

Acute Tox. 4 Oral - Carc. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

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Sigma-Aldrich

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In clinical practice, when ability to perceive bitter taste is studied, quinine is preferred to phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) as taste stimulus, because many subjects are genetically non-tasters for PTC/PROP. However, it is poorly known how sensitive anterior (front)
A Rambaldi et al.
The Cochrane database of systematic reviews, (4)(4), CD002800-CD002800 (2005-10-20)
Randomised clinical trials have addressed the question whether propylthiouracil has any beneficial effects in patients with alcoholic liver disease. To assess the beneficial and harmful of propylthiouracil for patients with alcoholic liver disease. The Cochrane Hepato-Biliary Group Controlled Trials Register
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Journal of pediatric endocrinology & metabolism : JPEM, 25(3-4), 331-343 (2012-07-10)
Antithyroid drugs (ATDs) have been widely and effectively used for the treatment of pediatric and adult thyrotoxicosis for more than a half century. Since the very beginning of ATD use, reports of hepatic dysfunction related to propylthiouracil (PTU) therapy have
C Vanek et al.
Thyroid : official journal of the American Thyroid Association, 15(1), 80-84 (2005-02-03)
Antineutrophil cytoplasmic antibodies (ANCA) are associated with vasculitis, including vasculitis induced by drugs such as the thionamides. The affected organ systems in thionamide-induced vasculitis have been primarily renal, musculoskeletal, and dermatologic. We describe the first case of thionamide-induced central nervous
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The Cochrane database of systematic reviews, (2)(2), CD002800-CD002800 (2002-06-22)
Alcohol is the most common cause of liver disease in the Western world today. Randomised clinical trials have addressed the question whether propylthiouracil has any efficacy in patients with alcoholic liver disease. The objectives were to assess the efficacy of
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