07858

(R)-(−)-3-Amino-1-Boc-piperidin

≥98.0% (TLC)

• Synonym(e): (R)-1-Boc-3-piperidinamin, (R)-3-Amino-1-piperidincarbonsäure-tert.-butylester
• Empirische Formel (Hill-System): C₁₀H₂₀N₂O₂
• CAS-Nummer: 188111-79-7
• Molekulargewicht: 200.28
• MDL-Nummer: MFCD03094717
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 329748523
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98.0% (TLC)
• Optische Aktivität: [α]/D -28.5±2°, c = 1 in DMF
• SMILES String: CC(C)(C)OC(=O)N1CCC[C@@H](N)C1
• InChI: 1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(11)7-12/h8H,4-7,11H2,1-3H3/t8-/m1/s1
• InChIKey: AKQXKEBCONUWCL-MRVPVSSYSA-N

Beschreibung

Allgemeine Beschreibung

(R)-3-Amino-1-Boc-piperidine can be used as a precursor for the preparation of dipeptidyl peptidase IV inhibitors like linagliptin, alogliptin, and other antidiabetic agents.

Anwendung

(R)-3-Amino-1-Boc-piperidine can be used to prepare a benzoxazepine derivative named (R)-7-(3,5-dimethoxyphenyl)-N-(piperidin-3-yl)-4-propionyl-2,3,4,5-tetrahydro-1,4-benzoxazepine-9-carboxamide, a potent CBP/P300 bromodomain inhibitor.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter