8.52199

Fmoc-Asp(OtBu)-Thr(psiMe,Mepro)-OH

Novabiochem^®

• Synonym(e): Fmoc-Asp(OtBu)-Thr(psiMe,Mepro)-OH
• Empirische Formel (Hill-System): C₃₀H₃₆N₂O₈
• CAS-Nummer: 920519-32-0
• Molekulargewicht: 552.62
• UNSPSC-Code: 12352209
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Produktlinie: Novabiochem^®
• Assay: ≥95% (TLC); ≥97.0% (HPLC)
• Form: powder
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: hydroxyl
• Lagertemp.: 2-8°C
• InChI: 1S/C30H36N2O8/c1-17-25(27(35)36)32(30(5,6)39-17)26(34)23(15-24(33)40-29(2,3)4)31-28(37)38-16-22-20-13-9-7-11-18(20)19-12-8-10-14-21(19)22/h7-14,17,22-23,25H,15-16H2,1-6H3,(H,31,37)(H,35,36)/t17-,23+,25+/m1/s1
• InChIKey: NKQJRYSIZOXCTJ-LAMXGVLKSA-N

Beschreibung

Allgemeine Beschreibung

This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Asp-Thr dipeptide motif. It consists of a dipeptide in which the threonine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The threonine residue is regenerated during the normal TFA-mediated cleavage reaction.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Verlinkung

Replaces: 05-20-1126

Hinweis zur Analyse

Farbe (visuell): weiß bis schwach gelb bis beige
Aussehen der Substanz (visuell): Pulver
Identität (IR): entspricht
Optische Drehung α 25/D (c=1 in Methanol): -23.5 - -18.5 °
Reinheit (DC(011A)): ≥ 95 %
Gehalt (HPLC, Fl.%): ≥ 97.0 % (a/a)
Verunreinigungen (einzeln): ≤ 1.00 % (a/a)
Ethylacetat (HS-GC): ≤ 2.0 %
Acetat (IC): ≤ 0.1 %
DC-Bedingungen gemäß den Angaben unseres Hauptkataloges

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable