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Sigma-Aldrich

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

for peptide synthesis

Synonym(e):

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

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500 MG
CHF 36.70
1 G
CHF 47.30
5 G
CHF 131.00
25 G
CHF 342.00

CHF 36.70


Voraussichtliches Versanddatum29. Mai 2025


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500 MG
CHF 36.70
1 G
CHF 47.30
5 G
CHF 131.00
25 G
CHF 342.00

About This Item

Empirische Formel (Hill-System):
C8H17N3 · xHCl
CAS-Nummer:
Molekulargewicht:
155.24 (free base basis)
MDL-Nummer:
UNSPSC-Code:
12352107
EG-Index-Nummer:
247-361-2
NACRES:
NA.22

CHF 36.70


Voraussichtliches Versanddatum29. Mai 2025


Bulk-Bestellung anfordern

Produktbezeichnung

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, for synthesis

Qualitätsniveau

Form

solid

Eignung der Reaktion

reaction type: Coupling Reactions

mp (Schmelzpunkt)

110-115 °C

Anwendung(en)

peptide synthesis

Lagertemp.

−20°C (−15°C to −25°C)

SMILES String

Cl.N(CCCN(CC)C#N)(C)C

InChI

1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H

InChIKey

FDXPUDRRFDHONO-UHFFFAOYSA-N

Allgemeine Beschreibung

N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, also known as EDAC HCl or WSC, is a water-soluble condensing reagent. EDAC HCl is generally used to couple carboxylic acids with amines to form amides. The by-product urea is water-soluble and can be removed from immiscible reaction milieux by extraction with water. It is principally utilized in solution-phase peptide synthesis and as a zero-length crosslinker for protein modification.

Anwendung

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) can be used as:
  • A water-soluble carbodiimide to facilitate peptide coupling reactions in alcohols.[1]
  • A coupling agent along with HOBt to synthesize poly(glutamic acid) (PGA) polypeptides for the creation of non-fouling polypeptides that could be useful in a variety of biomedical applications.[2]
  • A coupling reagent for the efficient synthesis of teriflunomide at the industrial scale.[3]

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral

Lagerklassenschlüssel

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. The packaging instructions recommend storing the item under an inert gas, but the safety data sheet does not specify this requirement. Would it suffice to store it in a refrigerator at -20°C instead?

    1 answer
    1. The recommended long term storage of this item is -15°C to -25°C. Clearing the headspace of the vial with argon before resealing is recommended. The stability of the product when stored otherwise cannot be guaranteed.

      Helpful?

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