5.30509

StemSelect Compound E

≥95% (HPLC), liquid, γ-secretase inhibitor, Calbiochem^®

• Synonym(e): StemSelect Compound E, ( S, S)- 2-(2-(3,5-Difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide, InSolution γ-Secretase Inhibitor XXI, Compound E
• Empirische Formel (Hill-System): C₂₇H₂₄F₂N₄O₃
• CAS-Nummer: 209986-17-4
• Molekulargewicht: 490.50
• MDL-Nummer: MFCD04974531
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: StemSelect Compound E,
• Assay: ≥95% (HPLC)
• Qualitätsniveau: 100
• Form: liquid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Lagertemp.: −70°C
• SMILES String: Fc1cc(cc(c1)CC(=O)N[C@@H](C)C(=O)NC2N=C(c4c(cccc4)N(C2=O)C)c3ccccc3)F
• InChI: 1S/C27H24F2N4O3/c1-16(30-23(34)14-17-12-19(28)15-20(29)13-17)26(35)32-25-27(36)33(2)22-11-7-6-10-21(22)24(31-25)18-8-4-3-5-9-18/h3-13,15-16,25H,14H2,1-2H3,(H,30,34)(H,32,35)/t16-,25?/m0/s1
• InChIKey: JNGZXGGOCLZBFB-YPHZTSLFSA-N

Beschreibung

Allgemeine Beschreibung

Notch signaling suppressor.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
presenilins

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Physikalische Form

A 5 mM (250 µg/102 µl), 0.2 µm-filtered solution in DMSO.

Rekonstituierung

Following initial use, aliquot and freeze (-70°C).

Sonstige Hinweise

Li, W., et al. 2011. Proc. Natl Acad. Sci. USA108, 8299.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): 188.6 °F - (refers to pure substance)
• Flammpunkt (°C): 87 °C - (refers to pure substance)