47589-M

Mitomycin C, Streptomyces caespitosus

• Synonym(e): Mitomycin C, Streptomyces caespitosus, Mitocin C, MMC
• Empirische Formel (Hill-System): C₁₅H₁₈N₄O₅
• CAS-Nummer: 50-07-7
• Molekulargewicht: 334.33
• MDL-Nummer: MFCD00078109
• UNSPSC-Code: 12352200

Eigenschaften

• Assay: ≥95% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: blue-violet
• Löslichkeit: water: 1 mg/mL
• Lagertemp.: 2-8°C
• InChI: 1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
• InChIKey: NWIBSHFKIJFRCO-WUDYKRTCSA-N

Beschreibung

Allgemeine Beschreibung

Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues, disrupting base pairing. Induces apoptosis in gastic cancer cells. Blocks the cell cycle at the G2 phase.

Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Forms covalent adducts into deoxyguanine and guanine under acidic conditions. Induces apoptosis in gastric cancer cells. Blocks the cell cycle at the G₂ phase.

Warnhinweis

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Physikalische Form

Provided as 2 mg antibiotic and 48 mg NaCl.

Rekonstituierung

Following reconstitution, store in the refrigerator (4°C) for short-term storage and in a freezer (-20°C) for longer term. Stock solutions are stable for up to 2 weeks at 4°C and up to 3 months at -20°C.

Sonstige Hinweise

Kruyt, F.A., et al. 1996. Blood 89, 938.
Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst.87, 1394.
Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
Kawasaki, S., et al. 1992. Jpn. J. Cancer Res.83, 899.
Malkinson, A.M., et al. 1992. Cancer Res.52, 4752.
McEvoy, J.L., et al. 1992. J. Bacteriol.174, 5471.
Tomasz, M., et al. 1987. Science235, 1204.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H302,H351
• P-Sätze: P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Carc. 2
• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3