171262

AMPK Activator V, Ampkinone

The AMPK Activator V, Ampkinone modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Biochemicals applications.

• Synonym(e): AMPK Activator V, Ampkinone, AKN, AMPK Signaling Activator V
• Empirische Formel (Hill-System): C₃₁H₂₃NO₆
• CAS-Nummer: 1233082-79-5
• Molekulargewicht: 505.52
• MDL-Nummer: MFCD28143482
• UNSPSC-Code: 12352200
• NACRES: NA.51

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: yellow
• Löslichkeit: DMSO: 25 mg/mL
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C
• SMILES String: OC1=C(OC)C=CC2=C1OC(C)(C)C3=C2C=CC4=C3C(N(C5=CC=C(C(C6=CC=CC=C6)=O)C=C5)C4=O)=O
• InChIKey: BRRCHDIWBKOMEC-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable benzopyran compound that stimulates both LKB1 and CaMKK-mediated AMPK activity indirectly with no noticeable effect on purified AMPK, cellular AMP/ATP ratio, PI 3-K/Akt signaling and respiratory chain, and displays antidiabetic and antiobesity properties. Shown to induce phosphorylation of AMPK-Thr¹⁷² and ACC-Ser⁷⁹ in L6 cells (EC₅₀ = 4.3 µM), C2C12 myocytes, 3T3-L1 preadipocytes and HepG2 hepatic cells, and enhance glucose uptake and insulin sensitivity in high fat-diet-induced obesity mouse model (10 mg/kg, s.c.) with the lowering of cholesterol and nonesterified fatty acids.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Regulatory Review (Z)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sonstige Hinweise

Oh, S., et al. 2010. J. Med. Chem.53, 7405.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable