05-536
Anti-IKKα Antibody, clone 14A231
clone 14A231, Upstate®, from mouse
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100 X 1 μG
CHF 388.00
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100 X 1 μG
CHF 388.00
About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
mouse
Qualitätsniveau
Antikörperform
purified immunoglobulin
Antikörper-Produkttyp
primary antibodies
Klon
14A231, monoclonal
Speziesreaktivität
human, monkey, mouse
Hersteller/Markenname
Upstate®
Methode(n)
western blot: suitable
Isotyp
IgG1
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... CHUK(1147)
Spezifität
Recognizes IKKα.
Immunogen
His-tagged, full length human IKKα
Anwendung
Research Category
Zelluläre Signaltransduktion
Zelluläre Signaltransduktion
Research Sub Category
Immunologische Signalübertragung
Immunologische Signalübertragung
Anti-IKKα Antibody, clone 14A231 is an antibody against IKKα for use in WB.
Qualität
routinely evaluated by immunoblot on RIPA lysates from Jurkat cells
Zielbeschreibung
85 kDa
Physikalische Form
Format: Purified
Protein G purified IgG1 in PBS containing 0.05% sodium azide.
Lagerung und Haltbarkeit
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Hinweis zur Analyse
Control
Positive Antigen Control: Catalog #12-309, Hela cell nuclear extract. Add an equal volume of Laemmli reducing sample buffer to 10 μL of extract and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced extract per lane for minigels.
Positive Antigen Control: Catalog #12-309, Hela cell nuclear extract. Add an equal volume of Laemmli reducing sample buffer to 10 μL of extract and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced extract per lane for minigels.
Rechtliche Hinweise
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Se-Ran Yang et al.
American journal of respiratory cell and molecular biology, 40(2), 147-158 (2008-08-09)
The activation of transcription factor NF-kappaB is controlled by two main pathways: the classical canonical (RelA/p65-p50)- and the alternative noncanonical (RelB/p52)-NF-kappaB pathways. RelB has been shown to play a protective role in RelA/p65-mediated proinflammatory cytokine release in immune-inflammatory lymphoid cells.
Daniela S Bassères et al.
Genes & cancer, 5(1-2), 41-55 (2014-06-24)
Activating mutations in KRAS are prevalent in cancer, but therapies targeted to oncogenic RAS have been ineffective to date. These results argue that targeting downstream effectors of RAS will be an alternative route for blocking RAS-driven oncogenic pathways. We and
Hong Dong et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(26), e2123247119-e2123247119 (2022-06-24)
Mitochondria, a highly metabolically active organelle, have been shown to play an essential role in regulating innate immune function. Mitochondrial Ca2+ uptake via the mitochondrial Ca2+ uniporter (MCU) is an essential process regulating mitochondrial metabolism by targeting key enzymes involved
Willie Wilson et al.
Cancer research, 68(19), 8156-8163 (2008-10-03)
Constitutive nuclear factor kappaB (NF-kappaB) activation is among the many deregulated signaling pathways that are proposed to drive pancreatic cancer cell growth and survival. Recent reports suggest that glycogen synthase kinase-3beta (GSK-3beta) plays a key role in maintaining basal NF-kappaB
José A García et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(9), 3863-3875 (2015-06-06)
We determined the NF-κB- and NOD-like receptor (NLR)P3-dependent molecular mechanisms involved in sepsis and evaluated the role of retinoid-related orphan receptor (ROR)-α in melatonin's anti-inflammatory actions. Western blot, RT-PCR, ELISA, and spectrophotometric analysis revealed that NF-κB and NLRP3 closely interact
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