860508P

C8 Ceramide (d18:1/8:0)

Avanti Research^™ - A Croda Brand 860508P, powder

• Synonym(e): N-octanoyl-D-erythro-sphingosine
• Empirische Formel (Hill-System): C₂₆H₅₁NO₃
• CAS-Nummer: 74713-59-0
• Molekulargewicht: 425.69
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Form: powder
• Verpackung: pkg of 1 × 5 mg (860508P-5mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 860508P
• Lipid-Typ: sphingolipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
• InChI: 1S/C26H51NO3/c1-3-5-7-9-10-11-12-13-14-15-16-18-19-21-25(29)24(23-28)27-26(30)22-20-17-8-6-4-2/h19,21,24-25,28-29H,3-18,20,22-23H2,1-2H3,(H,27,30)/b21-19+/t24-,25+/m0/s1
• InChIKey: APDLCSPGWPLYEQ-WRBRXSDHSA-N

Beschreibung

Allgemeine Beschreibung

C8 Ceramide is a short chain ceramide and is cell permeable.

Anwendung

C8 Ceramide (d18:1/8:0) has been used as an internal ceramide standard in electrospray ionization. It has also been used as a substrate for ceramide kinase activity assay. It is suitable for use as a substrate for galactocerebrosidase.

Biochem./physiol. Wirkung

C8 Ceramide has anti-tumor functionality. Synthetic liposomal C8 ceramide inhibits hepatocellular carcinoma (HCC). Addition of exogenous C8 ceramide causes necrosis in hepatocytes by decreasing ATP levels and impairing mitochondrial functionality. C8 ceramide inhibition of serine palmitoyl transferase halts de novo sphingolipid biosynthesis. It also acts as chemotherapeutic agent by increasing the reactive oxygen species in lung cancer cells.

Verpackung

5 mL Amber Glass Screw Cap Vial (860508P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids