Alle Fotos(2)
Wichtige Dokumente
857392O
Avanti
(R)-FTY720-OMe
(R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol, neat oil
Synonym(e):
(R)-FTY720-methyl ether; ROME
Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Größe auswählen
1 MG
CHF 159.00
Alle Fotos(2)
Größe auswählen
Ansicht ändern
1 MG
CHF 159.00
About This Item
Empirische Formel (Hill-System):
C20H35NO2
CAS-Nummer:
Molekulargewicht:
321.50
MDL-Nummer:
UNSPSC-Code:
12352211
NACRES:
NA.25
Empfohlene Produkte
Assay
>99% (TLC)
Form
liquid
Verpackung
pkg of 1 × 1 mg (857392O-1mg)
Hersteller/Markenname
Avanti Research™ - A Croda Brand 857392O
Lipid-Typ
sphingolipids
bioactive lipids
Versandbedingung
dry ice
Lagertemp.
−20°C
Verwandte Kategorien
Allgemeine Beschreibung
(R)-FTY720-OMe is the analogue of FTY720.[1]
(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity.
Biochem./physiol. Wirkung
(R)-FTY720-OMe helps to block DNA synthesis and actin rearrangement induced by sphingosine 1-phosphate (S1P) in MCF-7 breast cancer cells. It can also reduce sphingosine kinase 2 (SK2) expression and prevent DNA synthesis in HEK 293 cells. (R)-FTY720-OMe has anti-breast cancer potential.[1]
Verpackung
5 mL Amber Glass Screw Cap Vial (857392O-1mg)
Rechtliche Hinweise
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 3
Hier finden Sie alle aktuellen Versionen:
Analysenzertifikate (COA)
Lot/Batch Number
It looks like we've run into a problem, but you can still download Certificates of Analysis from our Dokumente section.
Wenn Sie Hilfe benötigen, wenden Sie sich bitte an Kundensupport
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Francesca Tonelli et al.
British journal of pharmacology, 168(6), 1497-1505 (2012-11-02)
Sphingosine kinase catalyses the formation of sphingosine 1-phosphate and is linked with androgen receptor signalling in prostate cancer cells. Therefore, we investigated the effect of sphingosine kinase inhibitors on androgen receptor expression. Androgen-sensitive LNCaP cells were treated with SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole)
(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells
Lim KG, et al.
Cellular Signalling, 23(10), 1590-1595 (2011)
Keng Gat Lim et al.
Cellular signalling, 23(10), 1590-1595 (2011-05-31)
Sphingosine kinase 2 (SK2) catalyses the conversion of sphingosine to the bioactive lipid sphingosine 1-phosphate (S1P). We report here, the stereospecific synthesis of an analogue of FTY720 called (R)-FTY720-OMe, which we show is a competitive inhibitor of SK2. (R)-FTY720-OMe failed
David G Watson et al.
Cellular signalling, 25(4), 1011-1017 (2013-01-15)
Two isoforms of sphingosine kinase, SK1 and SK2, catalyze the formation of the bioactive lipid sphingosine 1-phosphate (S1P) in mammalian cells. We have previously shown that treatment of androgen-sensitive LNCaP prostate cancer cells with a non-selective SK isoform inhibitor, 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
Setzen Sie sich mit dem technischen Dienst in Verbindung.
