810603C

16:0-10 Doxyl PC

Avanti Research^™ - A Croda Brand 810603C

• Synonym(e): 1-palmitoyl-2-stearoyl-(10-doxyl)-sn-glycero-3-phosphocholine
• Empirische Formel (Hill-System): C₄₆H₉₀N₂O₁₀P
• CAS-Nummer: 188004-25-3
• Molekulargewicht: 862.19
• MDL-Nummer: MFCD02259246
• UNSPSC-Code: 41141825
• NACRES: NA.12

Eigenschaften

• Assay: >99% (TLC)
• Form: liquid
• Verpackung: pkg of 1 × 1 mL (810603C-1mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 810603C
• Konzentration: 1 mg/mL (810603C-1mg)
• Lipid-Typ: ESR probes; phospholipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

Avanti′s nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins and as fluorescent quenchers in lipid bilayer structural studies.[1][2]

Phosphocholine is considered as a precursor molecule. It is formed during the breakdown of phosphatidylcholine metabolism.[3]

Anwendung

16:0-10 Doxyl PC may be used in vesicles for quenching PT-(1–46)F4W fluorescence.[4] It may also be used in vesicles to check the fluorescence emission spectra in order to measure the penetration depth of the peptides′ tryptophan residues in lipid bilayer.[5]

Biochem./physiol. Wirkung

Phosphatidylcholine (PC) lowers the levels of cholesterol and triglycerides.[6]

Verpackung

5 mL Clear Glass Sealed Ampule (810603C-1mg)

Angaben zur Herstellung

Product use: To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies.[7] For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM [2], Additional supplemental information.

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• P-Sätze: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Zielorgane: Central nervous system, Liver,Kidney
• WGK: WGK 3