791056P
Avanti
2-OHOA
2-hydroxyoleic acid (sodium salt), powder
Synonym(e):
Minerval; NaCHOleate; 2OHOA
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About This Item
Empirische Formel (Hill-System):
C18H33NaO3
CAS-Nummer:
Molekulargewicht:
320.44
MDL-Nummer:
UNSPSC-Code:
12352211
NACRES:
NA.25
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Assay
>99% (TLC)
Form
powder
Verpackung
pkg of 1 × 1 g (791056P-1g)
Hersteller/Markenname
Avanti Research™ - A Croda Brand 791056P
Lipid-Typ
neutral lipids
neutral glycerides
Versandbedingung
dry ice
Lagertemp.
−20°C
Allgemeine Beschreibung
2-hydroxyoleic acid (2-OHOA) is a synthetic and non-β oxidation-metabolizable oleic acid derivative. It contains 18 carbon atoms in its fatty acid chain length.
Anwendung
2-hydroxyoleic acid (2-OHOA) is suitable for use:
- to study its antihypertensive action in adult spontaneously hypertensive rats (SHRs)
- to study the chemical structure-effect relation of 2-OHOA in the reduction of body weight in rats
- as an antitumor compound, to study its effect on xenografts lipidome based on imaging mass spectrometry (IMS)
Biochem./physiol. Wirkung
2-Hydroxy Oleic Acid is an inducer of cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2-Hydroxy Oleic Acid increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.
2-hydroxyoleic acid (2-OHOA) acts as a potential antihypertensive agent. Oral administration of 2-OHOA is used to reduce body weight.
Verpackung
20 mL Clear Glass Screw Cap Vial (791056P-1g)
Rechtliche Hinweise
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Lagerklassenschlüssel
11 - Combustible Solids
Hier finden Sie alle aktuellen Versionen:
Analysenzertifikate (COA)
Lot/Batch Number
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Silvia Terés et al.
Autophagy, 8(10), 1542-1544 (2012-08-16)
The very high mortality rate of gliomas reflects the unmet therapeutic need associated with this type of brain tumor. We have discovered that the plasma membrane fulfills a critical role in the propagation of tumorigenic signals, whereby changes in membrane
2-Hydroxyoleic acid: a new hypotensive molecule
Alemany R, et al.
Hypertension, 43(2), 249-254 (2004)
Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats
Vogler O, et al.
International Journal of Obesity, 32(3), 464-464 (2008)
Victoria Lladó et al.
Biochimica et biophysica acta, 1838(6), 1619-1627 (2014-02-15)
This review summarizes the cellular bases of the effects of NaCHOleate (2-hydroxyoleic acid; 2OHOA; Minerval) against glioma and other types of tumors. NaCHOleate, activates sphingomyelin synthase (SGMS) increasing the levels of cell membrane sphingomyelin (SM) and diacylglycerol (DAG) together with
Antihypertensive action of 2-hydroxyoleic acid in SHRs via modulation of the protein kinase A pathway and Rho kinase
Alemany R
Journal of Lipid Research, 47(8), 1762-1770 (2006)
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