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790981P

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14:0 PE-DTPA (Gd)

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt), powder

Synonym(e):

1,2-ditetradecanoyl-sn-glycero-3-phosphoethanolamine- N-diethylenetriaminepentaacetic acid (gadolinium salt); DMPE-DTPA (Gd)

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CHF 177.00

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About This Item

Empirische Formel (Hill-System):
C47H90GdN6O17P
CAS-Nummer:
827020-81-5
Molekulargewicht:
1199.47
MDL-Nummer:
MFCD00057815
UNSPSC-Code:
12352211
NACRES:
NA.25

CHF 177.00

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Assay

>99% (TLC)

Form

powder

Verpackung

pkg of 1 × 5 mg (790981P-5mg)

Hersteller/Markenname

Avanti Research™ - A Croda Brand 790981P

Lipid-Typ

phospholipids

Versandbedingung

dry ice

Lagertemp.

−20°C

Allgemeine Beschreibung

14:0 PE-DTPA (Gd) has been used as a paramagnetic lipid to probe the orientation of a membrane protein in respect to the phospholipid bilayer membrane.[1]
Lipid nanoparticles containing DMPE-DTPA(Gd) provide high quality contrast enhanced vascular MRI at 97% reduced dose of Gd and do not rely on renal clearance. Structure as shown by Cormode, D.P. et al.

Verpackung

5 mL Amber Glass Screw Cap Vial (790981P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

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Analysenzertifikate (COA)

Lot/Batch Number

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David P Cormode et al.
Nano letters, 8(11), 3715-3723 (2008-10-23)
High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by incorporation of gold, iron oxide, or quantum dot nanocrystals
Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR
Hagn F, et al.
Nature Protocols, 13(1), 79-79 (2018)
Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform.
Cormode DP, et al.
Nano Letters, 8, 3715-3723 (2008)
Alessandra Barazza et al.
Bioconjugate chemistry, 24(6), 1039-1048 (2013-04-27)
We have previously reported enhancing the imaging of atherosclerotic plaques in mice using reconstituted high density lipoproteins (HDL) as nanocarriers for the MRI contrast agent gadolinium (Gd). This study focuses on the underlying mechanisms of Gd delivery to atherosclerotic plaques.
Tot Bui et al.
PloS one, 5(9) (2010-10-12)
Gadolinium (Gd), with its 7 unpaired electrons in 4f orbitals that provide a very large magnetic moment, is proven to be among the best agents for contrast enhanced MRI. Unfortunately, the most potent MR contrast agent based on Gd requires
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