923818

N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide

• Synonym(e): Coumarin alkyne CoLDR probe
• Empirische Formel (Hill-System): C₁₇H₁₅NO₄
• Molekulargewicht: 297.31
• MDL-Nummer: MFCD34602236
• UNSPSC-Code: 12352200
• NACRES: NA.22

Eigenschaften

• Eignung der Reaktion: reagent type: chemical modification reagent; reaction type: click chemistry
• Qualitätsniveau: 100
• Funktionelle Gruppe: (Alkyne)
• Lagertemp.: 2-8°C
• SMILES String: O=C1OC2=CC(OCC(C(NCCC#C)=O)=C)=CC=C2C=C1
• InChIKey: MTTOLTREJYBDSH-UHFFFAOYSA-N

Beschreibung

Anwendung

N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide is a proteomic cysteine probe. As described in Reddi et al, the Nir London lab developed a-substituted N-alkynyl-methacrylamides for covalent ligand directed release chemistry (CoLDR). CoLDR represents a new type of acrylamide-based electrophiles for targeted covalent inhibitor discovery and design. Specifically this CoLDR probe is a coumarin derivative with a terminal alkyne for click chemistry.

Sonstige Hinweise

Chemical Biology Tools

Click Chemistry Reagents

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable