532703

1-Brom-4-chlor-2-fluorbenzol

98%

• Lineare Formel: BrC₆H₃(Cl)F
• CAS-Nummer: 1996-29-8
• Molekulargewicht: 209.44
• MDL-Nummer: MFCD00079708
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24877906
• NACRES: NA.22

Eigenschaften

• Assay: 98%
• Brechungsindex: n20/D 1.556 (lit.)
• bp: 91-92 °C/20 mmHg (lit.)
• Dichte: 1.678 g/mL at 25 °C (lit.)
• SMILES String: Fc1cc(Cl)ccc1Br
• InChI: 1S/C6H3BrClF/c7-5-2-1-4(8)3-6(5)9/h1-3H
• InChIKey: FPNVMCMDWZNTEU-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

1-Bromo-4-chloro-2-fluorobenzene is a polyhalo substituted benzene. It undergoes Suzuki coupling with 2-cyanoarylboronic esters to form the corresponding biphenyls. These biphenyls are the precursors for synthesizing 6-substituted phenanthridines.† The enthalpy of vaporization at boiling point (467.15K) of 1-bromo-4-chloro-2-fluorobenzene is 40.737kjoule/mol.{4}

Anwendung

1-Bromo-4-chloro-2-fluorobenzene may be used in the preparation of benzonorbornadiene derivative. It may also be used as a starting material in the multi-step synthesis of AZD3264, an IKK2 (inhibitor of nuclear factor κ-B kinase-2) inhibitor.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): 198.0 °F - closed cup
• Flammpunkt (°C): 92.2 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)