498327

2-Fluoracetessigsäure-ethylester

• Synonym(e): 2-Fluor-3-oxobutansäure-ethylester, Ethyl-2-fluor-3-oxobutanoat, Ethyl-2-fluor-3-oxobutyrat, NSC 24563
• Lineare Formel: CH₃COCH(F)CO₂C₂H₅
• CAS-Nummer: 1522-41-4
• Molekulargewicht: 148.13
• MDL-Nummer: MFCD00215830
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24873190

Eigenschaften

• Brechungsindex: n20/D 1.414 (lit.)
• bp: 183 °C (lit.)
• Dichte: 1.181 g/mL at 25 °C (lit.)
• SMILES String: CCOC(=O)C(F)C(C)=O
• InChI: 1S/C6H9FO3/c1-3-10-6(9)5(7)4(2)8/h5H,3H2,1-2H3
• InChIKey: SHTFQLHOTAJQRJ-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Ethyl 2-fluoroacetoacetate is an α-fluorinated β-keto ester that can be prepared by the fluorination of ethyl acetoacetate.

Anwendung

Ethyl 2-fluoroacetoacetate may be used in the preparation of:

• δ-keto-β-hydroxy-α-fluoro esters
• fluorinated [1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-ones
• fluorinated [1,2,4]triazolo[5,1-c][1,2,4]triazin-4(1H)-ones
• 4-fluorofarnesol

Reactant for:

• Michael addition-induced cyclization reaction
• Asymmetric Mannich reaction
• Enantioselective organocatalytic conjugate addition

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): 194.0 °F - closed cup
• Flammpunkt (°C): 90 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type ABEK (EN14387) respirator filter