The long term storage temperature of the product 447139 is at room temperature. This information can be found in the MSDS sheet. This document is available from our website.
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447439
1-Methyl-L-tryptophan
95%, for peptide synthesis
Synonym(e):
(S)-2-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid, L-(-)-1-Methyltryptophan
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CHF 52.30
5 G
CHF 159.00
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1 G
CHF 52.30
5 G
CHF 159.00
About This Item
Empirische Formel (Hill-System):
C12H14N2O2
CAS-Nummer:
Molekulargewicht:
218.25
MDL-Nummer:
UNSPSC-Code:
12352209
PubChem Substanz-ID:
NACRES:
NA.22
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Produktbezeichnung
1-Methyl-L-tryptophan, 95%
Qualitätsniveau
Assay
95%
Form
solid
Optische Aktivität
[α]24/D −8.0°, c = 2 in acetic acid
Eignung der Reaktion
reaction type: solution phase peptide synthesis
mp (Schmelzpunkt)
242-245 °C (lit.)
Anwendung(en)
peptide synthesis
SMILES String
Cn1cc(C[C@H](N)C(O)=O)c2ccccc12
InChI
1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1
InChIKey
ZADWXFSZEAPBJS-JTQLQIEISA-N
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Anwendung
1-Methyl-L-tryptophan can be used:
- In the preparation of L-tryptophan-based ligand for regioselective copper catalyzed N2-arylation of 1,2,3-triazoles.[1]
- As a key starting material for the total synthesis of (−)-ardeemin.[2]
- In the synthesis of cyclic peptide-capped gold nanoparticles as drug delivery systems.[3]
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Stefanie Siegert et al.
PloS one, 6(11), e27618-e27618 (2011-11-24)
Adaptive immune responses are initiated when T cells encounter antigen on dendritic cells (DC) in T zones of secondary lymphoid organs. T zones contain a 3-dimensional scaffold of fibroblastic reticular cells (FRC) but currently it is unclear how FRC influence
Cyclic peptide-capped gold nanoparticles as drug delivery systems.
Nasrolahi Shirazi A, et al.
Molecular Pharmaceutics, 10(2), 500-511 (2012)
Development of a L?Tryptophan?Based Ligand for Regioselective Copper Catalyzed N2?Arylation of 1, 2, 3?Triazoles.
Lopes A B, et al.
ChemistrySelect, 2(22), 6544-6548 (2017)
Christiane A Opitz et al.
PloS one, 6(5), e19823-e19823 (2011-06-01)
1-methyl-D-tryptophan (1-D-MT) is currently being used in clinical trials in patients with relapsed or refractory solid tumors with the aim of inhibiting indoleamine-2,3-dioxygenase (IDO)-mediated tumor immune escape. IDO is expressed in tumors and tumor-draining lymph nodes and degrades tryptophan (trp)
Jeroen F J Bogie et al.
Journal of neuroinflammation, 8, 85-85 (2011-07-26)
Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) in which macrophages play a central role. Initially, macrophages where thought to be merely detrimental in MS, however, recent evidence suggests that their functional phenotype
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What conditions do you recommend for long term storage of Product No. 447439, 1-Methyl-L-tryptophan?
1 answer-
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The name of Product No. 447439 is "1-Methyl-L-tryptophan, 95%". How is that purity value determined?
1 answer-
The purity of Product No. 447439 is based on elemental analysis. That is, the assayed values for percent carbon and nitrogen should be within about 95% of their theoretical values. But the speification sheet does not report an overall purity value per se.
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How do you recommend dissolving Product No. 447439, 1-Methyl-L-tryptophan?
1 answer-
This product is soluble in 0.5 N Hydrochloric acid at 50 mg/mL. Based on information from one of our customers (not confirmed in our labs), this product is also soluble in 0.1 N sodium hydroxide at a 20 mM concentration. It is not soluble in DMSO.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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