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Sigma-Aldrich

N-Benzyl-2-nitro-1H-imidazol-1-acetamid

97%

Synonym(e):

2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide, Benzonidazol, N-Benzyl-2-nitroimidazol-1-yl-acetamide

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About This Item

Empirische Formel (Hill-System):
C12H12N4O3
CAS-Nummer:
22994-85-0
Molekulargewicht:
260.25
MDL-Nummer:
MFCD00243089
UNSPSC-Code:
12352100
PubChem Substanz-ID:
24866267
NACRES:
NA.22

Assay

97%

mp (Schmelzpunkt)

189-192 °C (lit.)

Löslichkeit

methanol: soluble 50 mg/mL, clear, colorless to yellow

SMILES String

[O-][N+](=O)c1nccn1CC(=O)NCc2ccccc2

InChI

1S/C12H12N4O3/c17-11(14-8-10-4-2-1-3-5-10)9-15-7-6-13-12(15)16(18)19/h1-7H,8-9H2,(H,14,17)

InChIKey

CULUWZNBISUWAS-UHFFFAOYSA-N

Allgemeine Beschreibung

N-Benzyl-2-nitro-1H-imidazole-1-acetamide (Benznidazole) is a nitro-heterocyclic compound. It is widely employed drug for the treatment of Chagas disease. It exhibits three polymorphic forms..

Anwendung

N-Benzyl-2-nitro-1H-imidazole-1-acetamide (Benznidazole) may be used as reference drug for the extraction of guaianolide from the aerial parts of Tanacetum parthenium and to evaluate its in vitro antiprotozoal activity.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Susana Revollo et al.
Pathogens (Basel, Switzerland), 8(4) (2019-10-23)
We ascertain the in vitro Benznidazole (BZN) and Nifurtimox (NFX) susceptibility pattern of epimastigotes, trypomastigotes, and amastigotes of 21 T. cruzi strains, from patients, reservoir, and triatomine bugs of various geographic origins. Using this panel of isolates, we compute the
María-Jesús Pinazo et al.
Antimicrobial agents and chemotherapy, 57(1), 390-395 (2012-11-02)
For treating Chagas disease (CD), a current worldwide health problem, only benznidazole and nifurtimox have been approved to be used. In both cases, unwanted drug-related adverse events (ADRs) are frequent when these drugs are used in adults in the chronic
Ana P M Teston et al.
Tropical medicine & international health : TM & IH, 18(1), 85-95 (2012-11-08)
To assess the susceptibility of Trypanosoma cruzi strains from Amazon to benznidazole. We studied 23 strains of T. cruzi obtained from humans in the acute phase of Chagas disease, triatomines and marsupials in the state of Amazonas and from chronic
Juliana Cogo et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(1), 59-66 (2012-10-17)
In the present study, we evaluated the in vitro antiprotozoal activity of a guaianolide (11,13-dehydrocompressanolide) isolated from Tanacetum parthenium against Trypanosoma cruzi and investigated the possible combinational effect of guaianolide and benznidazole. The isolated compound was shown to be effective
Miriam Navarro et al.
The American journal of tropical medicine and hygiene, 87(3), 489-490 (2012-07-25)
Chagas disease is a neglected tropical disease endemic in Latin America. The first-line treatment option is benznidazole, but stocks are expected to run out in the coming months. Spain would need around 5 million benznidazole tablets. This drug shortage could
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