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285366

2-(4-Chlorphenoxy)-2-methyl-propionsäure-ethylester

Name: 2-(4-Chlorphenoxy)-2-methyl-propionsäure-ethylester
Brand: ALDRICH

99%

Synonym(e):

Clofibrate

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About This Item

Empirische Formel (Hill-System):

C₁₂H₁₅ClO₃

CAS-Nummer:

637-07-0

Molekulargewicht:

242.70

Beilstein:

1913459

MDL-Nummer:

MFCD00000615

UNSPSC-Code:

12352101

PubChem Substanz-ID:

329753222

Assay

99%

bp

154-156 °C/20 mmHg (lit.)

Dichte

1.14 g/mL at 25 °C (lit.)

SMILES String

CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1

InChI

1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3

InChIKey

KNHUKKLJHYUCFP-UHFFFAOYSA-N

Angaben zum Gen

human ... PPARA(5465)

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Probing the fibrate binding specificity of rat liver fatty acid binding protein.

Sara Chuang et al.

Journal of medicinal chemistry, 52(17), 5344-5355 (2009-08-12)

Liver-fatty acid binding protein (L-FABP) is found in high levels in enterocytes and is involved in cytosolic solubilization of fatty acids. In addition, L-FABP has been shown to bind endogenous and exogenous lipophilic compounds, suggesting that it may also play

Floratheasaponins A-C, acylated oleanane-type triterpene oligoglycosides with anti-hyperlipidemic activities from flowers of the tea plant (Camellia sinensis).

Masayuki Yoshikawa et al.

Journal of natural products, 68(9), 1360-1365 (2005-09-27)

The methanolic extract and its n-butanol-soluble fraction from the flowers of the tea plant (Camellia sinensis) were found to suppress serum triglyceride elevation in olive oil-treated mice. From the n-butanol-soluble fraction, three new acylated oleanane-type triterpene oligoglycosides, floratheasaponins A-C (1-3)

Perennisosides I-VII, acylated triterpene saponins with antihyperlipidemic activities from the flowers of Bellis perennis.

Toshio Morikawa et al.

Journal of natural products, 71(5), 828-835 (2008-03-28)

The methanolic extract and its saponin fraction (methanol-eluted fraction) of the flowers of Bellis perennis were found to suppress serum triglyceride elevation in olive oil-treated mice. From the saponin fraction, seven new triterpene saponins, perennisosides I (1), II (2), III

Novel use of a lipid-lowering fibrate medication to prevent nicotine reward and relapse: preclinical findings.

Leigh V Panlilio et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(8), 1838-1847 (2012-03-29)

Experimental drugs that activate α-type peroxisome proliferator-activated receptors (PPARα) have recently been shown to reduce the rewarding effects of nicotine in animals, but these drugs have not been approved for human use. The fibrates are a class of PPARα-activating medications

Identification, organ expression and ligand-dependent expression levels of peroxisome proliferator activated receptors in grass carp (Ctenopharyngodon idella).

Shan He et al.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 155(2), 381-388 (2011-11-15)

The peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors belonging to the nuclear receptor family, and can regulate various genes involved in lipid metabolism. The aim of the present study was to investigate the tissue distribution patterns of PPARs and

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