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258385

Sigma-Aldrich

Protoporphyrin IX Dinatriumsalz

≥90% (HPLC)

Synonym(e):

3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphindipropionsäure Dinatriumsalz, Depocolin-S, Ooporphyrin Dinatriumsalz

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5 G
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250 MG
CHF 76.50
1 G
CHF 243.00
5 G
CHF 846.00

About This Item

Empirische Formel (Hill-System):
C34H32N4Na2O4
CAS-Nummer:
Molekulargewicht:
606.62
Beilstein:
5227034
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352103
PubChem Substanz-ID:
NACRES:
NA.23

CHF 76.50


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Assay

≥90% (HPLC)

Form

powder

λmax

406 nm

Lagertemp.

2-8°C

SMILES String

[Na+].[Na+].Cc1c(CCC([O-])=O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC([O-])=O

InChI

1S/C34H34N4O4.2Na/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16,36-37H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42);;/q;2*+1/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;

InChIKey

JZRNDUPVNXWZDY-HXFTUNQESA-L

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Anwendung

Protoporphyrin disodium salt (PpIX) was used as a dye content for fluorescence spectroscopic characterization in a study. [1] The cytotoxic effect of PpIX on sarcoma 180 solid tumors cells was reported in a study. [2][3]

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Kunden haben sich ebenfalls angesehen

Fluorescence spectroscopic characterization of salivary metabolites of oral cancer patients.
Yuvaraj M, et al.
Journal of Photochemistry and Photobiology. B, Biology, 130, 153-160 (2014)
Sonodynamic effects of protoporphyrin IX disodium salt on isolated sarcoma 180 cells
Liu Q, et al.
Ultrasonics, 45(1-4), 56-60 (2006)
Kiwamu Takahashi et al.
Anticancer research, 33(7), 2861-2866 (2013-06-20)
5-Aminolevulinic acid (ALA) is a precursor of heme. ALA is used as a photosensitive substance in photodynamic diagnosis (PDD) and photodynamic therapy (PDT) because heme metabolism is abnormal in tumor cells and a photosensitive metabolite of heme synthesis from ALA
Pan Wang et al.
Ultrasonics, 53(5), 935-942 (2013-02-19)
Protoporphyrin IX (PpIX) has been used as a sensitizer in photodynamic therapy (PDT) as well as in sonodynamic therapy (SDT). The photo-bleaching of PpIX has been well investigated in many experimental systems and some photo-products have also been identified in
Kana Unuma et al.
PloS one, 8(2), e56526-e56526 (2013-03-05)
Lipopolysaccharide (LPS)-induced myocardial dysfunction is caused, at least in part, by mitochondrial dysfunction. Mitochondrial dysfunction and the oxidative damage associated with it are scavenged through various cellular defense systems such as autophagy to prevent harmful effects. Our recent study has

Artikel

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Questions

1–2 of 2 Questions  
  1. To study interaction of porphyrin with a protein, how should a solution of this compound be made for flourescence quenching?

    1 answer
    1. This is not an application that is tested internally, but there is evidence in literature (Iwunze MO. The fluorescence study of the quenching of nanoemulsion by protoporphyrin IX (PPIX). Material Sci & Eng. 2022;6(3):97‒99. DOI: 10.15406/mseij.2022.06.00185) that concentrations between 6.45 x 10-7 M to 3.24 x 10-6 M PPIX are effective for quenching. Another author describes the quenching of protein fluorescence by PPIX by using a solution concentration range of 1×10−5 M to 3×10−4 M excited at 280 nm and 1x10−5 M to 3×10−4 M excited at 295 nm (Characteristics of the Protoporphyrin IX Binding Sites on Human Serum Albumin Using Molecular Docking, Molecules 2016, 21(11), 1519).

      Helpful?

  2. What is the water solubility of PPIX-disodium?

    1 answer
    1. This chemical is known to be soluble in chloroform or methanol and slightly soluble in water. The concentration at which this product is solubilized is not determined.

      Helpful?

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