211672

Nipecotinsäure

98%

• Synonym(e): 3-Piperidincarbonsäure
• Empirische Formel (Hill-System): C₆H₁₁NO₂
• CAS-Nummer: 498-95-3
• Molekulargewicht: 129.16
• EG-Nummer: 207-873-9
• MDL-Nummer: MFCD00005992
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24278161
• NACRES: NA.22

Eigenschaften

• Assay: 98%
• Form: solid
• mp (Schmelzpunkt): 261 °C (dec.) (lit.)
• Löslichkeit: water: soluble 50 mg/mL, clear, colorless to faintly yellow
• Funktionelle Gruppe: carboxylic acid
• SMILES String: OC(=O)C1CCCNC1
• InChI: 1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9)
• InChIKey: XJLSEXAGTJCILF-UHFFFAOYSA-N
• Angaben zum Gen: human ... SLC23A2(9962)

Beschreibung

Allgemeine Beschreibung

R(−)-Nipecotic acid is a potential inhibitor of uptake of γ-aminobutyric acid (GABA) in rat brain slices[1]. Lipophilic derivatives of nipecotic acid are used as drugs for the treatment of epilepsy[2].

Anwendung

Nipecotic acid was used in determination of the antiepileptic drug vigabatrin and the amino acid neurotransmitters in rat brain extracellular fluid by capillary electrophoresis with laser-induced fluorescence detection[3].

Reactant for concurrent esterification and N-acteylation of amino acids with orthoesters

Reactant for synthesis of:
Anticonvulsants
HCV NS5B polymerase inhibitors
Cathepsin S inhibitors
Orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation
Positive allosteric modulator of metabotropic glutamate receptor 4

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves