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1-(4-Fluorphenyl)-piperazin
98%
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About This Item
Empirische Formel (Hill-System):
C10H13FN2
CAS-Nummer:
Molekulargewicht:
180.22
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352100
PubChem Substanz-ID:
NACRES:
NA.22
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Assay
98%
Form
solid
bp
118-123 °C/0.1 mmHg (lit.)
mp (Schmelzpunkt)
30-33 °C (lit.)
SMILES String
Fc1ccc(cc1)N2CCNCC2
InChI
1S/C10H13FN2/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
InChIKey
AVJKDKWRVSSJPK-UHFFFAOYSA-N
Angaben zum Gen
rat ... Chrnb2(54239)
Anwendung
1-(4-Fluorophenyl)piperazine was used in the synthesis of N,N-disubstituted piperazine.
Signalwort
Warning
H-Sätze
P-Sätze
Gefahreneinstufungen
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Zielorgane
Respiratory system
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Craig A Stockmeier et al.
Journal of psychiatric research, 43(10), 887-894 (2009-02-14)
Serotonin-1A receptors may play a role in the pathophysiology of depression and suicide. In postmortem brain tissue, agonist binding to serotonin-1A receptors is reportedly increased or unchanged in depression or suicide, while neuroimaging studies report a decrease in antagonist binding
P E Keane et al.
Neuropharmacology, 21(2), 163-169 (1982-02-01)
Niaprazine (60 mg/kg i.p.) increased rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Rat brain 5-hydroxytryptamine (5-HT) levels were unchanged. Niaprazine also produced a short-lasting depletion of rat brain
Rapid synthesis of N, N'-disubstituted piperazines. Application to the preparation of No carrier added 1-(4-[18F] fluorophenyl) piperazine and of an [18F]-selective ligand of serotoninergic receptors (5HT2 antagonist).
Collins M, et al.
Journal of the Chemical Society. Perkin Transactions 1, 23, 3185-3188 (1992)
Camilla Montesano et al.
Drug testing and analysis, 9(5), 798-807 (2016-07-28)
In this paper, an analytical method has been developed and validated for the analysis of new psychoactive substances (NPS) and metabolites in hair samples. The method was based on pressurized liquid extraction (PLE) followed by solid-phase extraction (SPE) clean-up and
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