113980

7-Methoxyindol

97%

• Synonym(e): NSC 100739
• Empirische Formel (Hill-System): C₉H₉NO
• CAS-Nummer: 3189-22-8
• Molekulargewicht: 147.17
• EG-Nummer: 221-690-1
• MDL-Nummer: MFCD00047203
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24847155

Eigenschaften

• Assay: 97%
• Brechungsindex: n20/D 1.612 (lit.)
• bp: 108-110 °C/0.3 mmHg (lit.)
• Dichte: 1.126 g/mL at 25 °C (lit.)
• SMILES String: COc1cccc2cc[nH]c12
• InChI: 1S/C9H9NO/c1-11-8-4-2-3-7-5-6-10-9(7)8/h2-6,10H,1H3
• InChIKey: FSOPPXYMWZOKRM-UHFFFAOYSA-N

Beschreibung

Anwendung

7-Methoxyindole is used to study the effects of methoxy and amino substitution on the indole ring.

• Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
• Reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors
• Reactant for preparation of benzoylpiperazinyl-indolyl ethane dione derivatives as HIV-1 inhibitors
• Reactant for preparation of bis(indolyl)alkanehydroxamic acids as histone deacetylase inhibitors
• Reactant for preparation of β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2

Biochem./physiol. Wirkung

7-Methoxyindole inhibits tobacco cell growth that can be partially reversed by indole and tryptophan.

Sicherheitshinweise

• Piktogramme: GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H302,H315,H318,H335
• P-Sätze: P261 - P280 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): >235.4 °F - closed cup
• Flammpunkt (°C): > 113 °C - closed cup
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves