112968

Methylhydrochinon

99%

• Synonym(e): 2,5-Dihydroxy-toluol
• Lineare Formel: CH₃C₆H₃-1,4-(OH)₂
• CAS-Nummer: 95-71-6
• Molekulargewicht: 124.14
• Beilstein: 2041489
• EG-Nummer: 202-443-7
• MDL-Nummer: MFCD00002345
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24847123
• NACRES: NA.22

Eigenschaften

• Assay: 99%
• Form: solid
• Selbstzündungstemp.: 851 °F
• mp (Schmelzpunkt): 128-130 °C (lit.)
• SMILES String: Cc1cc(O)ccc1O
• InChI: 1S/C7H8O2/c1-5-4-6(8)2-3-7(5)9/h2-4,8-9H,1H3
• InChIKey: CNHDIAIOKMXOLK-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Methylhydroquinone is produced by the oxidation of o-cresol by the mutants G103S, G103S/A107G, and G103S/A107T.

Anwendung

Methylhydroquinone can be used as a reactant to prepare:

• A semiflexible thermotropic polyester via polycondensation reaction with 4,4′-sebacoyldioxydibenzoyl chloride.
• A sesquiterpene (±)-helibisabonol A.
• poly{hexakis[(methyl)(4-hydroxyphenoxy)]cyclotriphosphazene} by reacting with hexachlorocyclotriphosphazene.
• 6-Hydroxy-4,7-dimethyl-2H-1-benzopyran-2-one by treating with ethyl acetoacetate in the presence of H₂SO₄ as a catalyst.

Biochem./physiol. Wirkung

Methylhydroquinone (Toluquinol) inhibits the growth of endothelial and tumor cells in culture in the micromolar range and is a promising drug candidate in the treatment of cancer and other angiogenesis-related pathologies.

Sicherheitshinweise

• Piktogramme: GHS05,GHS07,GHS09
• Signalwort: Danger
• H-Sätze: H314,H317,H335,H410
• P-Sätze: P260 - P271 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Gefahreneinstufungen: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A - Skin Sens. 1 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 8A - Combustible corrosive hazardous materials
• WGK: WGK 2
• Flammpunkt (°F): 341.6 °F - closed cup
• Flammpunkt (°C): 172 °C - closed cup
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves