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V6383

Sigma-Aldrich

Vinpocetine

≥98%, solid

Synonyme(s) :

(3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester, Eburnamenine-14-carboxylic acid ethyl ester

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About This Item

Formule empirique (notation de Hill):
C22H26N2O2
Numéro CAS:
42971-09-5
Poids moléculaire :
350.45
Numéro CE :
256-028-0
Numéro MDL:
MFCD00211233
Code UNSPSC :
41106305
ID de substance PubChem :
24278182
Nomenclature NACRES :
NA.77

Niveau de qualité

200

Pureté

≥98%

Forme

solid

Couleur

white

Solubilité

DMSO: 5 mg/mL
H2O: insoluble

Chaîne SMILES 

[H][C@]12N3CCC[C@@]1(CC)C=C(C(=O)OCC)n4c2c(CC3)c5ccccc45

InChI

1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1

Clé InChI

DDNCQMVWWZOMLN-IRLDBZIGSA-N

Informations sur le gène

human ... PDE1A(5136) , PDE1B(5153) , PDE1C(5137)

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Actions biochimiques/physiologiques

Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Attention

Photosensitive

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Tomasz Sozański et al.
Pharmacological reports : PR, 63(5), 1258-1263 (2011-12-20)
Previous studies proved that food strongly enhanced the bioavailability of vinpocetine. Food may change the pharmacokinetics of a drug by affecting various factors, including gastrointestinal pH. However, the influence of proton pump inhibitor-induced pH alterations on vinpocetine pharmacokinetics is not
A A Skoromets et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 113(4), 18-24 (2013-06-07)
Authors studied impairment of cognitive functions in 180 patients, aged 56-74 years, with chronic blood flow deficiency in the vertebrobasilar territory. Along with neurological examination, we used MRI of the brain and the cervical spine, MRI-angiography, ultrasound Doppler method, EEG
Klintsy Julieta Torres et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 30(3), 711-722 (2012-08-03)
In multiple sclerosis during periods of remission a limited degree of myelin repair can be observed mediated by oligodendroglial precursor cells. Phosphodiesterase inhibitors act as anti-inflammatory agents and might hold promise for future multiple sclerosis treatment. To investigate whether phosphodiesterase
Alexei V Muravyov et al.
Clinical hemorheology and microcirculation, 49(1-4), 431-439 (2012-01-05)
This study was designed to evaluate hemorheological changes in patients with cerebrovascular disease (CVD) and peripheral arterial disease (PAD) after 4 weeks of pentoxifylline therapy as well as to study red blood cell microrheological variables after the cell incubation with
Yan-Ting Mao et al.
Die Pharmazie, 68(5), 381-382 (2013-06-28)
The purpose of the present study was to develop a novel transdermal vinpocetine patch containing a stable formulation and with good entrapment efficiency, and percutaneous absorption which via ethosome. Ethosome was found to be a more efficient delivery carrier with
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