SML1954

X-34

≥90% (HPLC), powder, amyloid-specific fluorescent dye

• Synonyme(s) : 1,4-Bis(3-carboxy-4-hydroxyphenylethenyl)benzene
• Formule empirique (notation de Hill) : C₂₄H₁₈O₆
• Numéro CAS: 215294-98-7
• Poids moléculaire : 402.40
• Numéro MDL: MFCD30474509
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Nom du produit: X-34, ≥90% (HPLC)
• Niveau de qualité: 100
• Essai: ≥90% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 2.0 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: OC(C=C1)=C(C(O)=O)C=C1C=CC2=CC=C(C=CC3=CC=C(O)C(C(O)=O)=C3)C=C2
• InChI: 1S/C24H18O6/c25-21-11-9-17(13-19(21)23(27)28)7-5-15-1-2-16(4-3-15)6-8-18-10-12-22(26)20(14-18)24(29)30/h1-14,25-26H,(H,27,28)(H,29,30)
• Clé InChI: MCBNOAYTZBUCSX-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Fluorescent, amyloid-specific dye

X-34 (1,4-bis(3-carboxy-4-hydroxyphenylethenyl)-benzene) is one among the small-molecule γ-secretase modulators (GSMs) involved in lowering Aβ42 levels (the 42-residue isoform of the amyloid-β peptide). X-34 has also been used to visualize intracellular immunoreactive deposits with classic amyloid fibrillar ultrastructure in living transgenic Caenorhabditis elegans animals. It is also used as a histochemical stain for determining pathological changes in Alzheimer′s disease (AD).

X-34 is a fluorescent, amyloid-specific dye. It binds at a different site than Pittsburgh Compound B and is a highly fluorescent marker for beta-sheet structures.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable