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SML0679

Sigma-Aldrich

Danshensu sodium salt

≥98% (HPLC)

Synonyme(s) :

(R)-α,3,4-Trihydroxy-benzenepropanoic acid sodium salt, (R)-(+)-3-(3,4-Dihydroxyphenyl)lactic acid, 3-(3′,4′-Dihydroxyphenyl)-(2R)-lactic acid sodium salt, DS 182, Dan Shen Su, Dan shen suan A, Salianic acid A, Salvianic acid A

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About This Item

Formule empirique (notation de Hill):
C9H9O5 · Na
Numéro CAS:
81075-52-7
Poids moléculaire :
220.15
Numéro MDL:
MFCD07781415
Code UNSPSC :
12352200
ID de substance PubChem :
329825582
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Activité optique

[α]/D +30 to +40°, c = 1 in H2O

Couleur

white to beige

Solubilité

H2O: 20 mg/mL, clear

Température de stockage

2-8°C

Chaîne SMILES 

OC1=C(O)C=CC(C[C@@H](O)C([O-])=O)=C1.[Na+]

InChI

1S/C9H10O5.Na/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;/h1-3,8,10-12H,4H2,(H,13,14);/q;+1/p-1/t8-;/m1./s1

Clé InChI

ZMMKVDBZTXUHFO-DDWIOCJRSA-M

Actions biochimiques/physiologiques

Danshensu is an active component of Salvia miltiorrhiza (Danshen) that suppresses the formation of reactive oxygen species, inhibits platelet adhesion and aggregation, and protects myocardium against ischemia. Danshensu is cardioprotective, which protects myocardium from the reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Sunisa Seetapun et al.
Bioscience reports, 33(4), doi:10-doi:10 (2013-07-23)
Novel Danshensu derivatives (3-8) were designed and synthesized to improve bioactivity based on the strategy of 'medicinal chemical hybridization'. Our previous studies indicated that these compounds exhibited noticeable cardioprotective activities. Here, we investigate whether these novel Danshensu derivatives exert neuroprotective
Zihua Wang et al.
Analytica chimica acta, 1140, 145-152 (2020-11-22)
Interleukin-6 (IL-6) is of high importance for disease diagnosis and prognosis in human health since it's a crucial component in immune homeostasis, hematopoiesis, and metabolism. Herein, an immunosensor has been developed for monitoring IL-6, which is fabricated by Au nanoparticles
Ye Jin et al.
Journal of pharmaceutical and biomedical analysis, 77, 32-39 (2013-01-30)
The application of near infrared (NIR) spectroscopy for on-line quantitative monitoring of alcohol precipitation of the Danhong injection was investigated. For the NIR measurements, two fiber optic probes designed to transmit NIR radiation through a 2mm path length flow cell
Jian-ping Zhang et al.
Planta medica, 79(9), 744-752 (2013-05-24)
The traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza), first recorded in the "Shen Nong's Herbal Classic", has long been used to treat cardiovascular conditions, although the mechanism(s) underlying its effects remain unclear. Here, an iron dextran injection (50 mg ·
Juan Guo et al.
Environmental toxicology and pharmacology, 35(1), 117-130 (2013-01-01)
Salvianic acid A (SAA) is the main hydrophilic active ingredient of Salvia miltiorrhiza bunge, which has long been used to treat liver and heart disease in China. In the present study, we investigated the radioprotective effects of SAA against γ-radiation-induced
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