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SML0450

Sigma-Aldrich

5-BDBD

≥98% (HPLC)

Synonyme(s) :

5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one

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About This Item

Formule empirique (notation de Hill):
C17H11BrN2O2
Numéro CAS:
768404-03-1
Poids moléculaire :
355.19
Numéro MDL:
MFCD18086878
Code UNSPSC :
12352200
ID de substance PubChem :
329824730
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Essai

≥98% (HPLC)

Forme

powder

Couleur

white to beige

Solubilité

DMSO: 15 mg/mL (clear solution)

Température de stockage

2-8°C

Chaîne SMILES 

Brc1cccc(c1)C2=NCC(=O)Nc3c2oc4ccccc34

InChI

1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21)

Clé InChI

NKYMVQPXXTZHSF-UHFFFAOYSA-N

Catégories apparentées

Actions biochimiques/physiologiques

5-BDBD is a specific inhibitor of P2X4.
5-BDBD is a specific inhibitor of P2X4. The compound inhibits P2X4 currents in CHO cells with an IC50 of 500 nM.
In native tissues, 5-BDBD is considered as a beneficial antagonist to analyze the effect of P2X receptors (P2XRs) subtype P2X4R.

Caractéristiques et avantages

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000361573
0000361573
0000187933
0000187934
082M4609V

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

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Hyuck Joon Kwon et al.
Scientific reports, 6, 39302-39302 (2016-12-23)
Electrical stimulation (ES) is known to guide the development and regeneration of many tissues. However, although preclinical and clinical studies have demonstrated superior effects of ES on cartilage repair, the effects of ES on chondrogenesis remain elusive. Since mesenchyme stem
Ting Long et al.
Journal of neuroinflammation, 15(1), 245-245 (2018-09-01)
The mechanism underlying migraine chronification remains unclear. Central sensitization may account for this progression. The microglia P2X4 receptor (P2X4R) plays a pivotal role in the central sensitization of inflammatory and neuropathic pain, but there is no information about P2X4R in
Bing Hu et al.
Iranian journal of basic medical sciences, 21(4), 364-369 (2018-05-26)
P2X4R is expressed in immunocyte and lung tissues. It has been a focus in inflammatory responses recently. This study investigated whether blockage of P2X4R attenuates allergic inflammation by modulating T cell response in ovalbumin-sensitized mice. Ovalbumin was used to sensitize
Yun-Ming Tu et al.
Food & function, 8(12), 4336-4346 (2017-09-25)
Circulating levels of free fatty acids (FFAs) are often found to be increased in patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS). High plasma FFA levels may give rise to maladaptive macrophage activation and promote inflammatory responses
Claudio Coddou et al.
Neuroscience letters, 690, 219-224 (2018-10-27)
P2X receptors (P2XRs) are a family of ATP-gated ionic channels that are expressed in numerous excitable and non-excitable cells. Despite the great advance on the structure and function of these receptors in the last decades, there is still lack of
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Articles

P2 Receptors: P2X Ion Channel Family

We offer many products related to P2X ion channel family receptors for your research needs.

P2 Receptors: P2X Ion Channel Family

We offer many products related to P2X ion channel family receptors for your research needs.

P2 Receptors: P2X Ion Channel Family

We offer many products related to P2X ion channel family receptors for your research needs.

P2 Receptors: P2X Ion Channel Family

We offer many products related to P2X ion channel family receptors for your research needs.

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