SAB4500487

Anti-PARP (Cleaved-Asp²¹⁴) antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : ADP-ribosyltransferase 1, ADPRT, ADPRT1, PARP, pADPRT-1
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 24 kDa
• Espèces réactives: mouse, human
• Concentration: ~1 mg/mL
• Technique(s): ELISA: 1:20000; western blot: 1:500-1:1000
• Numéro d'accès NCBI: P09874
• Numéro d'accès UniProt: P09874
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: proteolytically cleaved (Asp214)
• Informations sur le gène: human ... PARP1(142)

Description

Description générale

Anti-PARP (Cleaved-Asp²¹⁴) Antibody detects endogenous levels of fragment of activated PARP (Cleaved-Asp²¹⁴) protein.

PARP1 (poly (ADP-ribose) polymerase 1) is a nuclear protein that consists of three functional domains. It belongs to the PARP family. It is located on chromosome 1q42.

Immunogène

The antiserum was produced against synthesized peptide derived from human PARP.

Immunogen Range: 165-214

Application

Anti-PARP (Cleaved-Asp214) antibody has been used in Western Blotting.

Actions biochimiques/physiologiques

PARP1 (poly (ADP-ribose) polymerase 1) participates in DNA repair. It serves as a facilitator of homologous recombination. It controls transcription by regulating chromatin structure, altering DNA methylation patterns, acting as a co-regulator of transcription factors and interacting with chromatin insulators. It also plays an important role in the protection of cardiovascular system.

Caractéristiques et avantages

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Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable