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P5248

Sigma-Aldrich

Etidronate disodium hydrate

≥97% (NMR), solid

Synonyme(s) :

Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate

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About This Item

Formule empirique (notation de Hill):
C2H6Na2O7P2 · xH2O
Numéro CAS:
7414-83-7
Poids moléculaire :
249.99 (anhydrous basis)
Numéro CE :
231-025-7
Numéro MDL:
MFCD00152567
Code UNSPSC :
12352200
ID de substance PubChem :
329820220
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥97% (NMR)

Forme

solid

Couleur

white

Pf

>300 °C

Solubilité

H2O: ≥10 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

[Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O

InChI

1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

Clé InChI

GWBBVOVXJZATQQ-UHFFFAOYSA-L

Application

Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).

Actions biochimiques/physiologiques

Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.
Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC50 = 80 μM) as compared to the nitrogen containing bisphosphonates

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Etidronate protects chronic ocular hypertension induced retinal oxidative stress and promotes retinal ganglion cells growth through IGF-1 signaling pathway
Su J and Huang M
European Journal of Pharmacology, 841, 75-81 (2018)
Ping Yin et al.
Bioresource technology, 128, 36-43 (2012-12-01)
Novel biomass-based adsorbents organophosphonic acid functionalized spent buckwheat hulls (OPA-BH) with 60 mesh were successfully employed to adsorb Au(III) ions from simulated wastewater. The adsorption kinetics and isotherms both in unary ion system and in ternary ions system were investigated
Michael R McClung et al.
Calcified tissue international, 92(1), 59-67 (2012-11-15)
This 2-year trial evaluated the efficacy and tolerability of a monthly oral regimen of risedronate. Postmenopausal women with osteoporosis were randomly assigned to double-blind treatment with risedronate 75 mg on 2 consecutive days each month (2CDM) or 5 mg daily.
Richard Choo et al.
International journal of radiation oncology, biology, physics, 85(5), 1239-1245 (2012-12-26)
Androgen deprivation therapy (ADT) has been used as an adjuvant treatment to radiation therapy (RT) for the management of locally advanced prostate carcinoma. Long-term ADT decreases bone mineral density (BMD) and increases the risk of osteoporosis. The objective of this
Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes
Griffin S, et al.
Biology of Reproduction (2018)
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