PHR1764

Colchicine

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonyme(s) : (S)-N-(5,6,7,9-tétrahydro-1,2,3,10-tétraméthoxy-9-oxobenzo[a]heptalén-7-yl)acétamide
• Formule empirique (notation de Hill): C₂₂H₂₅NO₆
• Numéro CAS: 64-86-8
• Poids moléculaire : 399.44
• Numéro Beilstein : 2228813
• Numéro CE : 200-598-5
• Numéro MDL: MFCD00078484
• Code UNSPSC : 41116107
• ID de substance PubChem : 329823598
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material; pharmaceutical secondary standard
• Niveau de qualité: 300
• Agence: traceable to BP 1150; traceable to Ph. Eur. C2580000; traceable to USP 1146006
• Famille d'API: colchicine, thiocolchicoside
• CofA (certificat d'analyse): current certificate can be downloaded
• Conditionnement: pkg of 400 mg
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Pf: 150-160 °C (dec.) (lit.)
• Application(s): pharmaceutical (small molecule)
• Format: neat
• Température de stockage: 2-8°C
• Chaîne SMILES: COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O
• InChI: 1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
• Clé InChI: IAKHMKGGTNLKSZ-INIZCTEOSA-N
• Informations sur le gène: human ... TUBA1A(7846) , TUBA1B(10376) , TUBA1C(84790) , TUBA3C(7278) , TUBA3E(112714) , TUBA4A(7277) , TUBB(203068) , TUBB1(81027) , TUBB2A(7280) , TUBB2B(347733) , TUBB3(10381) , TUBB4A(10382) , TUBB4B(10383) , TUBB6(84617) , TUBB8(347688)

Description

Description générale

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Colchicine is a drug used for the treatment of gout and certain rheumatic and nonrheumatic conditions. It is the major alkaloid in the plant Colchicum autumnale (meadow saffron).

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Colchicine may be used as a pharmaceutical reference standard for the determination of colchicine in human plasma at therapeutic concentrations by liquid chromatography–tandem mass spectrometry method.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H300,H340
• Conseils de prudence: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 2 Oral - Muta. 1B
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable