I2644

IL-2 human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• Synonyme(s) : IL-2, hIL-2, Interleukin-2, T-cell growth factor
• Numéro MDL: MFCD00165721
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• product name: Interleukin-2 human, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
• Source biologique: human
• Niveau de qualité: 200
• Produit recombinant: expressed in E. coli
• Forme: lyophilized powder
• Puissance: ≤700 EC₅₀
• Qualité: endotoxin tested
• Poids mol.: 15.5 kDa
• Conditionnement: pkg of 5X10 μg; pkg of 10 μg
• Technique(s): cell culture | mammalian: suitable
• Impuretés: ≤1 EU/μg
• Numéro d'accès UniProt: P60568
• Température de stockage: −20°C
• Informations sur le gène: human ... IL2(3558)

Description

Description générale

Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor.

Application

Interleukin-2 human has been used:

• in the stimulation of natural killer cells
• to study its ability to stimulate lymphocyte growth and prevent apoptosis
• as an antigen in enzyme-linked immunosorbent assay (ELISA), to analyse the human autoantibody reactivities in health and in type 1 diabetes mellitus

Actions biochimiques/physiologiques

Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages. It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the essential functions of regulatory T cells. It is implicated in autoimmune disease. IL-2 is associated with apoptosis and thus, possesses antitumor response. It mediates CD41⁺ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Forme physique

Lyophilized, 0.2 μm filtered, no additives.

Remarque sur l'analyse

The biological activity is measured by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)