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GW20009F

Sigma-Aldrich

Anti-Transferrin antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-Serotransferrin, Anti-Siderophilin

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

chicken

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

mouse, human, rat

Fabricant/nom de marque

Genway 15-288-20009F

Technique(s)

indirect ELISA: suitable
western blot: suitable

Numéro d'accès NCBI

NP_001054.1

Numéro d'accès UniProt

P02787

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TF(7018)

Catégories apparentées

Immunogène

Immunogen Sequence: GI # 4557871, sequence 1-698
Serotransferrin native protein.

Application

Anti-Transferrin antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200. It is also used for indirect ELISA.

Actions biochimiques/physiologiques

Transferrin is a glycoprotein that binds to and transports Fe3+ ions from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. It may also stimulate cell proliferation by supplying iron during DNA synthesis. Abnormal synthesis of transferrin may lead to accumulation of iron and microcytic hypochromic anemia.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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J Laskey et al.
Experimental cell research, 176(1), 87-95 (1988-05-01)
Transferrin is essential for cell proliferation and it was suggested that it may trigger a proliferative response following its interaction with receptors, serving as a growth factor. However, since the only clearly defined function of transferrin is iron transport, it
The role of transferrin in the mechanism of cellular iron uptake.
K Thorstensen et al.
The Biochemical journal, 271(1), 1-9 (1990-10-01)
H A Huebers et al.
Blood, 61(2), 283-290 (1983-02-01)
A mechanism is proposed by which apotransferrin is secreted from mucosal cells, loaded with iron in the intestinal lumen, and then the intact complex is taken into the cell. Within the cell, iron is released and transferred to the blood
E D Letendre et al.
Infection and immunity, 44(2), 320-325 (1984-05-01)
Hypoferremia, the reduction of plasma transferrin iron levels during infection, has been shown to control Neisseria meningitidis infection in mice. The exact nature of the mechanism that regulates this response has been obscure. We have previously shown that hypoferremia does
E Beutler et al.
Blood, 96(13), 4071-4074 (2000-12-09)
Hereditary atransferrinemia is a rare but instructive disorder that has previously been reported in only 8 patients in 6 families. It is characterized by microcytic anemia and by iron loading, and can be treated effectively by plasma infusions. We now
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