D7802

Daidzein

≥98% (TLC), powder, carbonic anhydrase (CA) inhibitor

• Synonyme(s) : 4′,7-Dihydroxy­iso­flavone, 7-Hydroxy-3-(4-hydroxy­phenyl)-4H-1-benzo­pyran-4-one, 7-Hydroxy-3-(4-hydroxy­phenyl)­chromone, Isoaurostatin
• Formule empirique (notation de Hill) : C₁₅H₁₀O₄
• Numéro CAS: 486-66-8
• Poids moléculaire : 254.24
• NACRES: NA.77
• PubChem Substance ID: 24278030
• UNSPSC Code: 12352202
• EC Number: 207-635-4
• MDL number: MFCD00016954
• Beilstein/REAXYS Number: 231523

Propriétés

• Nom du produit: Daidzein, ≥98%, synthetic
• InChI: 1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H
• InChI key: ZQSIJRDFPHDXIC-UHFFFAOYSA-N
• SMILES string: Oc1ccc(cc1)C2=COc3cc(O)ccc3C2=O
• biological source: synthetic
• assay: ≥98%
• form: powder
• mp: >290 °C
• solubility: DMSO: 10 mg/mL
• storage temp.: −20°C
• Quality Level: 200
• Gene Information: human ... ESR1(2099), ESR2(2100), UGT1A4(54657) ; mouse ... Aldh1a2(19378), Hexa(15211), Maoa(17161) ; rat ... Aldh1a2(116676)

Description

General description

Daidzein is an isoflavone present in soy.[1] It regulates oxidative stress, angiogenesis, cell growth and apoptosis.[2] Daidzein has antioxidant, antiestrogenic and antiatherogenic properties. It provides protection against osteoporosis.[3]

Application

Daidzein has been used:

• as a control to evaluate fertility in rats[4][5]
• to study its effects on ovarian cancer[6]
• to simulate in vitro antioxidant activity[7]

Biochem/physiol Actions

Daidzein is a phytoestrogen that is suggested to play a role in preventing hormone-induced cancers.[8] Arrests cell cycle at G₁ in Swiss 3T3 cells.[9]

Soy isoflavone daidzein protects against oxidative damage in liver cells induced by 7,12-dimethylbenz[a]anthracene (DMBA). Catalase and superoxide dismutase activity, down-regulated by DMBA, was restored by daidzein.

Packaging

Packaged under Argon.

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Classe de stockage: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves