D3669
3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester)
powder
Synonyme(s) :
DTSP, Di(N-succinimidyl) 3,3′-dithiodipropionate, Dithiobis(succinimidyl propionate), Lomant’s reagent
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A propos de cet article
Formule empirique (notation de Hill) :
C14H16N2O8S2
Numéro CAS:
Poids moléculaire :
404.42
UNSPSC Code:
12352106
NACRES:
NC.07
PubChem Substance ID:
EC Number:
260-931-5
Beilstein/REAXYS Number:
1518074
MDL number:
Form:
powder
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powder
Quality Segment
reaction suitability
reagent type: cross-linking reagent
solubility
chloroform: 50 mg/mL, DMF: soluble, acetone: soluble
storage temp.
−20°C
SMILES string
O=C(CCSSCCC(=O)ON1C(=O)CCC1=O)ON2C(=O)CCC2=O
InChI
1S/C14H16N2O8S2/c17-9-1-2-10(18)15(9)23-13(21)5-7-25-26-8-6-14(22)24-16-11(19)3-4-12(16)20/h1-8H2
InChI key
FXYPGCIGRDZWNR-UHFFFAOYSA-N
General description
3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) is a homobifunctional cross-linking reagent containing a cleavable disulfide linkage. It is typically coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5).
Application
3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) has been used as a protein cross-linker.
Features and Benefits
The disulfide linkage is cleavable by mild reduction.
Disclaimer
Avoid use of reducing agents during coupling reactions.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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M Darder et al.
Analytical chemistry, 71(24), 5530-5537 (2000-01-07)
Exposure of gold surfaces to solutions of dithiobis N-succinimidyl propionate (DTSP) gives rise to the modification of the surface with N-succinimidyl-3-thiopropionate (NSTP) which can, in turn, react with amino groups allowing for the covalent immobilization of enzymes such as horseradish
Protein phosphatases 2C regulate the activation of the Snf1-related kinase OST1 by abscisic acid in Arabidopsis.
Vlad F
Plant Cell, 21, 3170-3170 (2009)
M Gamero et al.
Biosensors & bioelectronics, 25(9), 2038-2044 (2010-02-23)
The design and characterization of a lactate biosensor using a nanostructured rough gold surface as a transducer is reported. The biosensor is developed by immobilization of lactate oxidase (LOx), on a rough gold electrode modified with a self-assembled monolayer of
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| D3669-1G | 04061833563472 |
| D3669-500MG | 04061833563489 |