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Principaux documents

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B1552

Sigma-Aldrich

Bromoenol lactone

≥98% (TLC)

Synonyme(s) :

BEL, E-6-(Bromoethylene)tetrahydro-3-(1-naphthyl)-2H-pyran-2-one

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About This Item

Formule empirique (notation de Hill) :
C16H13BrO2
Numéro CAS:
88070-98-8
Poids moléculaire :
317.18
Numéro MDL:
MFCD00270871
Code UNSPSC :
41106300
ID de substance PubChem :
24278257
Nomenclature NACRES :
NA.77

Source biologique

synthetic (organic)

Essai

≥98% (TLC)

Forme

powder

Puissance

636 nM Ki

Solubilité

DMSO: soluble (Dilute in aqueous medium immediately prior to use and store on ice for no more than 12 hours.)
degassed ethanol: soluble (Dilute in aqueous medium immediately prior to use and store on ice for no more than 12 hours.)

λmax

224 nm

Température de stockage

−20°C

Chaîne SMILES 

[H]\C(Br)=C1\CCC(C(=O)O1)c2cccc3ccccc23

InChI

1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+

Clé InChI

BYUCSFWXCMTYOI-ZRDIBKRKSA-N

Actions biochimiques/physiologiques

Potent, irreversible inhibitor of calcium-independent phospholipase A2 and of magnesium-dependent phosphatidate phosphohydrolase from P388D macrophages (IC50 = 8 μM); enzyme activated irreversible chymotrypsin inhibitor (Ki = 636 nM).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
0000432625
0000432625
0000254580
SLCR0538
SLCQ3559

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Current eye research, 37(6), 500-507 (2012-05-15)
Inhibition of VEGF in the eye is an important treatment modality for reducing proliferation and migration of retinal pigment epithelium (RPE) in age-related macular degeneration (AMD). Additionally, previous studies suggest calcium-independent phospholipase A(2) group VIA (iPLA(2)-VIA) to be a potential
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The Journal of general physiology, 137(1), 111-132 (2010-12-29)
We describe rapid massive endocytosis (MEND) of >50% of the plasmalemma in baby hamster kidney (BHK) and HEK293 cells in response to large Ca transients. Constitutively expressed Na/Ca exchangers (NCX1) are used to generate Ca transients, whereas capacitance recording and
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Drug treatments for hepatocellular carcinoma (HCC) often fail because of multidrug resistance (MDR). The mechanisms of MDR are complex but cancer stem cells (CSCs), which are able to self-renew and differentiate, have recently been shown to be involved. The deubiquitinating
C D Eiber et al.
Vision research, 151, 41-52 (2017-11-14)
The "blue-on" and "blue-off" receptive fields in retina and dorsal lateral geniculate nucleus (LGN) of diurnal primates combine signals from short-wavelength sensitive (S) cone photoreceptors with signals from medium/long wavelength sensitive (ML) photoreceptors. Three questions about this combination remain unresolved.
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Cells, 8(7) (2019-07-07)
Increased activity of secretory phospholipases A2 (sPLA2) type-II was previously observed in ileum of Crohn's disease (CD). Our aims were to explore the involvement of calcium-independent (i)PLA2β in the release of sPLA2s from the human mast cell (MC) line (HMC-1)
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Articles

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

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