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69453

Sigma-Aldrich

L-Homocysteine

≥98.0% (NT)

Synonyme(s) :

(S)-2-Amino-4-mercaptobutyric acid

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About This Item

Formule linéaire :
HSCH2CH2CH(NH2)COOH
Numéro CAS:
6027-13-0
Poids moléculaire :
135.18
Numéro CE :
227-891-0
Numéro MDL:
MFCD00151320
Code UNSPSC :
12352204
ID de substance PubChem :
329761669
Nomenclature NACRES :
NA.32

product name

L-Homocysteine, ≥98.0% (NT)

Niveau de qualité

100

Pureté

≥98.0% (NT)

Forme

powder

Activité optique

[α]/D 25.5±1.5°, c = 1 in 1 M HCl

Couleur

white

Pf

263-265 °C

Application(s)

cell analysis

Maladie(s) pertinente(s)

Alzheimer′s disease

Température de stockage

−20°C

Chaîne SMILES 

N[C@@H](CCS)C(O)=O

InChI

1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1

Clé InChI

FFFHZYDWPBMWHY-VKHMYHEASA-N

Description générale

L-homocysteine is used to diagnose homocystinuria.

Application

L-homocysteine has been used as a supplement in cell culture media.

Actions biochimiques/physiologiques

Elevated homocysteine levels in plasma and tissue are associated with brain atrophy in Alzheimer′s disease as well as in healthy eldery subjects. Increased homocysteine is due to deficiencies in vitamin B status, specifically folate, B6 and B12 vitamins, which act as cofactors for enzymes involved in homocysteine metabolism.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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K Mehlig et al.
Heart (British Cardiac Society), 99(23), 1761-1765 (2013-09-10)
An elevated level of total plasma homocysteine (tHcy) has been associated with risk of coronary heart disease (CHD). The level of tHcy is affected by lifestyle, in addition to genetic predisposition. The methylene tetrahydrofolate reductase (MTHFR) 677C>T polymorphism (rs1801133) is
SAGE open medicine, 286054-286054 (2014)
James J H Chong et al.
Journal of the American Heart Association, 8(1), e011028-e011028 (2019-01-01)
Background Neutrophil gelatinase-associated lipocalin ( NGAL ) or lipocalin 2 may promote atherosclerosis and plaque instability leading to increased risk of cardiac events. We investigated the relationships between plasma NGAL , cardiovascular disease biomarkers, and long-term cardiac events. Methods and
Sanne Visser et al.
American journal of obstetrics and gynecology, 211(4), 373-373 (2014-03-19)
The aim of this study was to investigate which nonclassic cardiovascular biomarkers are associated with persistent endothelial dysfunction after pregnancy in women with a history of hypertensive pregnancy disorders compared with women with uncomplicated pregnancies. This was a systematic review
Rajendra P Shukla et al.
Advanced healthcare materials, 8(15), e1900462-e1900462 (2019-06-27)
The antipsychotic clozapine is the most effective medication available for schizophrenia and it is the only antipsychotic with a known efficacious clinical range. However, it is dramatically underutilized due to the inability to test clozapine blood levels in finger-pricked patients'
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