S0252

Sulfobromophthalein disodium salt hydrate

used to study hepatocyte transport functions

• Synonyme(s) : BSP, Bromsulfalein sodium disodium salt hydrate
• Formule empirique (notation de Hill): C₂₀H₈Br₄Na₂O₁₀S₂ · xH₂O
• Numéro CAS: 123359-42-2
• Poids moléculaire : 838.00 (anhydrous basis)
• Numéro CE : 200-761-0
• Numéro MDL: MFCD00150017
• Code UNSPSC : 12171500
• ID de substance PubChem : 24899433
• Nomenclature NACRES : NA.47

Propriétés

• Niveau de qualité: 200
• Forme: powder
• Composition: Water (by Karl Fischer): ≤ 8%; ; Sodium (Na) anhydrous: 4.6-5.8%
• Couleur: white to light gray
• Solubilité: water: 50 mg/mL, clear to hazy
• λmax: 575-581 nm
• Application(s): diagnostic assay manufacturing; hematology; histology
• Température de stockage: room temp
• Chaîne SMILES: [Na+].[Na+].[H]O[H].Oc1ccc(cc1S([O-])(=O)=O)C2(OC(=O)c3c(Br)c(Br)c(Br)c(Br)c23)c4ccc(O)c(c4)S([O-])(=O)=O
• InChI: 1S/C20H10Br4O10S2.2Na.H2O/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;;1H2/q;2*+1;/p-2
• Clé InChI: CDTNUNQQEUGDSD-UHFFFAOYSA-L

Description

Application

Sulfobromophthalein disodium salt hydrate has been used as a positive control to study the interaction of 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic acid (AKBA) with organic anion transporter OATP1B3.

Actions biochimiques/physiologiques

Sulfobromophthalein (BSP) is a high affinity organic ion substrate for organic anion transporting polypeptides (OATPs) and has been used as a substrate for multidrug resistance associated protein 2 (Mrp2). BSP is transported into hepatocytes by OATPs and, after conjugation to glutathione, is excreted into bile by Mrp2. It was found to inhibit the aldo-keto reductase ARK1C20.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H317,H334
• Conseils de prudence: P261 - P280 - P342 + P311
• Classification des risques: Resp. Sens. 1 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves