38370

DIC

≥98.0% (GC), for peptide synthesis

• Synonyme(s) : N,N′-Diisopropylcarbodiimide
• Formule linéaire : (CH₃)₂CHN=C=NCH(CH₃)₂
• Numéro CAS: 693-13-0
• Poids moléculaire : 126.20
• Numéro Beilstein : 878281
• Numéro CE : 211-743-7
• Numéro MDL: MFCD00065689
• Code UNSPSC : 12352001
• ID de substance PubChem : 329755678
• Nomenclature NACRES : NA.22

Propriétés

• product name: DIC, purum, ≥98.0% (GC)
• Qualité: purum
• Niveau de qualité: 200
• Pureté: ≥98.0% (GC)
• Forme: liquid
• Capacité de réaction: reaction type: Coupling Reactions
• Indice de réfraction: n20/D 1.433 (lit.)
• Point d'ébullition: 145-148 °C (lit.)
• Densité: 0.815 g/mL at 20 °C (lit.); 0.815 g/mL at 20 °C
• Application(s): peptide synthesis
• Chaîne SMILES: CC(C)N=C=NC(C)C
• InChI: 1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
• Clé InChI: BDNKZNFMNDZQMI-UHFFFAOYSA-N
• Informations sur le gène: human ... EPHX2(2053) ; mouse ... Ephx2(13850)

Description

Description générale

N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.

Application

N,N′-Diisopropylcarbodiimide can be used:

• To synthesize lanthanide (Ln) guanidinate complexes via insertion of carbodiimide into the Ln-N bond of lanthanocene secondary amido complexes.
• To facilitate the cyclization of N-(β-Hydroxy)amides to form 2-oxazolines.
• To synthesize 1-isopropyl-2-alkoxycarbonyl-3-isopropyliminio-aziridine by reacting with alkyl diazoacetates in the presence of transition metal salts.

DIC can be used as:

• A coupling reagent for the synthesis of various esters and amides by treating carboxylic acids with phenols and amines respectively.
• A reagent for the conversion of alcohols to aldehydes or ketones in the presence of DMSO via modified Moffatt-type oxidation reaction.
• A reagent to facilitates the preparation of alkyl halides from corresponding alcohols via the formation of o-alkylisourea.

Alternative au dicyclohexylcarbodiimide en synthèse peptidique.

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08,GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H226,H317,H318,H330,H334
• Conseils de prudence: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classification des risques: Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 91.4 °F
• Point d'éclair (°C): 33 °C
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter