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Merck
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Key Documents

AB10000

Sigma-Aldrich

Anti-CHIP/STUB1 Antibody

Chemicon®, from goat

Synonyme(s) :

CHIP, STUB1

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

goat

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

human, chimpanzee

Fabricant/nom de marque

Chemicon®

Technique(s)

ELISA: suitable
western blot: suitable

Numéro d'accès NCBI

NM_005861.2

Numéro d'accès UniProt

Q9UNE7

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... STUB1(10273)

Description générale

U box domain E3 ubiquitin ligase. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP-induced degradation was observed for mutant and wild-type p53, which transiently associate with molecular chaperones Hsc70 and Hsp90 and can be diverted onto a degradation pathway through this association. Also, CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins.

Immunogène

Peptide with sequence DAFISENGWVEDY, from the C-terminus of the protein sequence according to NP_005852.

Application

This Anti-CHIP/STUB1 Antibody is validated for use in ELISA, WB for the detection of CHIP/STUB1.

Forme physique

Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Remarque sur l'analyse

Control
Positive Control: Highly expressed in brain, heart, skelatal muscle, pancreas and placenta. Weak expression in kidney, liver and lung.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Adam J Kanack et al.
Chembiochem : a European journal of chemical biology, 23(6), e202100633-e202100633 (2022-01-22)
The ubiquitin ligase C-terminus of Hsc70 interacting protein (CHIP) is an important regulator of proteostasis. Despite playing an important role in maintaining proteostasis, little progress has been made in developing small molecules that regulate ubiquitin transfer by CHIP. Here we
Adam J Kanack et al.
The Journal of biological chemistry, 293(8), 2735-2743 (2018-01-11)
The accumulation of misfolded proteins promotes protein aggregation and neuronal death in many neurodegenerative diseases. To counteract misfolded protein accumulation, neurons have pathways that recognize and refold or degrade aggregation-prone proteins. One U-box-containing E3 ligase, C terminus of Hsc70-interacting protein
Monte S Willis et al.
Cell biochemistry and function, 31(8), 724-735 (2013-04-05)
The carboxyl terminus of Hsp70-interacting protein (CHIP) is a ubiquitin ligase/cochaperone critical for the maintenance of cardiac function. Mice lacking CHIP (CHIP-/-) suffer decreased survival, enhanced myocardial injury and increased arrhythmias compared with wild-type controls following challenge with cardiac ischaemia
Roberto Mota et al.
American journal of cancer research, 7(9), 1948-1958 (2017-10-06)
Cancer cachexia is a severe wasting syndrome characterized by the progressive loss of lean body mass and systemic inflammation. Up to 80% of cancer patients experience cachexia, with 20-30% of cancer-related deaths directly linked to cachexia. Despite efforts to identify

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