8.55084

Aminomethyl NovaGel

Novabiochem^®

• Numéro CAS: 263858-31-7
• Code UNSPSC : 13111023
• Nomenclature NACRES : NA.22

Propriétés

• Gamme de produits: NovaGel; Novabiochem^®
• Niveau de qualité: 200
• Forme: beads
• Capacité de réaction: reaction type: Fmoc solid-phase peptide synthesis
• Fabricant/nom de marque: Novabiochem^®
• Application(s): peptide synthesis
• Groupe fonctionnel: amine
• Température de stockage: 2-8°C

Description

Description générale

Aminomethyl NovaGel is a PEG-PS resin which has been designed to meet the requirements of organic chemists for resins of high substitution coupled with broad solvent compatibility. This support has a nominal loading of 0.7 mmole/g – almost twice that of comparable resins – but still retains most of the swelling characteristics of conventional PEG-PS supports. It is prepared from a special high-swell version of AM resin by partial derivatization with methyl-PEG-p-nitrophenylcarbonate ^[1]. Resin functionality is provided by residual aminomethyl groups. The urethane linkage between the PEG and the base resin is stable to strongly acidic, basic and reducing conditions, ensuring minimal loss of PEG chains during synthesis. Furthermore, because the linker is not attached to the end of the PEG chains, if leaching of PEG does occur, the product is not contaminated with U.V. absorbing linker-PEG fragments which can complicate the nmr spectra and HPLC profiles of products obtained with other PEG-PS supports.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

^[1] J. H. Adams, et al. (1998) J. Org. Chem., 63, 3706.

Liaison

Replaces: 01-64-0283

Remarque sur l'analyse

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.60 - 0.90 mmol/g
TNBS-Test: passes test
Swelling Volume (in DMF): lot specific result
The PEG-PS resin is prepared from aminomethyl copoly (Styrene 1% DVB), 100 - 200 mesh.

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable