573096

STAT3 Inhibitor Peptide, Cell-Permeable

≥95% (HPLC), lyophilized solid, STAT3 inhibitor, Calbiochem^®

• Synonyme(s) : STAT3 Inhibitor Peptide, Cell-Permeable, PpYLKTK-mts, STAT3 Inhibitor IV
• Formule empirique (notation de Hill): C₉₂H₁₅₇N₂₀O₂₄P
• Poids moléculaire : 1958.32
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: STAT3 Inhibitor Peptide, Cell-Permeable, The STAT3 Inhibitor Peptide, Cell-Permeable controls the biological activity of STAT3.
• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: lyophilized solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white
• Solubilité: water: 1 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

Supplied as a trifluoroacetate salt.

A cell-permeable analog of the Stat3-SH2 domain-binding phospho-peptide (Cat. No. 573095) that contains a C-terminal membrane translocating sequence (MTS) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat3-dependent Src transformation with no effect on Stat3-independent Ras transformation.

A cell-permeable analog of the Stat3-SH2 domain-binding phosphopeptide (Cat. No. 573095) that contains a C-terminal mts (membrane translocating sequence) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat-3 dependent Src transformation with no effect on Stat-3 independent Ras transformation. The unphosphorylated inactive control peptide is also available under Cat. No. 573105.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Blocker of Stat3 activation

Product does not compete with ATP.

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Séquence

H-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH

Autres remarques

Turkson, J., et al. 2001. J. Biol. Chem.276, 45443.
Rojas, M., et al. 1998. Nat. Biotechnol.16, 370.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable