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407709

Sigma-Aldrich

Insulin, Zinc, Human, Recombinant, P. pastoris

Synonyme(s) :

Insulin, Zinc, Human, Recombinant, P. pastoris

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About This Item

Numéro CAS:
11061-68-0
Numéro MDL:
MFCD00131380
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

Stérilité

non-sterile

Niveau de qualité

200

Forme

solid

Activité spécifique

≥25 IU/mg (dry basis)

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze

Impuretés

<10 EU/mg Endotoxin (EU/mg protein)

Couleur

white to off-white

Solubilité

0.01 M HCl: soluble

Conditions d'expédition

wet ice

Température de stockage

−20°C

Clé InChI

PBGKTOXHQIOBKM-FHFVDXKLSA-N

Description générale

Recombinant, human insulin (zinc) expressed in P. pastoris. A peptide anabolic hormone produced by pancreatic β-cells.
Recombinant, human insulin (zinc) expressed in P. pastoris. Peptide anabolic hormone produced by pancreatic β-cells. Increases the synthesis of protein, fat, glycogen, and substrate oxidation in mitochondria. Interacts with membrane insulin receptor to cause its biological actions.

Avertissement

Toxicity: Standard Handling (A)

Notes préparatoires

Insulin is practically insoluble from pH 4.5-7.0.

Reconstitution

Following reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 6 weeks at 4°C.

Autres remarques

Mohan, C., et al. 1989. Curr. Topics Cell. Reg.30, 105.
Johnson, I.S. 1983. Science219, 632.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

nwg

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Mohan Sreelekshmi et al.
Journal of biochemical and molecular toxicology, 35(6), 1-8 (2021-03-03)
Glucokinase (GK), a key regulator of hepatic glucose metabolism in the liver and glucose sensor and mediator in the secretion of insulin in the pancreas, is not studied in detail for its therapeutic application in diabetes. Herein, we study the
Kapil Manglani et al.
Cell biology international, 46(3), 488-497 (2021-12-06)
Role of CDK5 and its inhibition in various neuronal processes and functions are well established. However, role of CDK5 and its inhibition in neuronal insulin-signaling and-resistance is not yet explored. In the present study, we investigated the effect of CDK5
Medha Sharma et al.
Cell communication and signaling : CCS, 20(1), 179-179 (2022-11-16)
The aim of the present study was to determine the role of individual PHLPP isoforms in insulin signaling and insulin resistance in neuronal cells. PHLPP isoforms were either silenced or overexpressed individually, and the effects were observed on individual Akt
Kerrie A Morrison et al.
Scientific reports, 12(1), 3532-3532 (2022-03-05)
Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction. A major advantage of extraction using copolymers rather than detergent is the retention of the lipid bilayer around the proteins. Here we report the first
Leying Chen et al.
eLife, 11 (2022-03-25)
Anti-epidermal growth factor receptor (EGFR) therapy-associated cutaneous toxicity is a syndrome characterized by papulopustular rash, local inflammation, folliculitis, and microbial infection, resulting in a decrease in quality of life and dose interruption. However, no effective clinical intervention is available for
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