124039

Akt Inhibitor X

InSolution, ≥97%

• Synonyme(s) : InSolution Akt Inhibitor X, 10-(4ʹ-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl, 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl, 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl, 10-(4ʹ-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl
• Formule empirique (notation de Hill): C₂₀H₂₅ClN₂O · xHCl
• Numéro CAS: 925681-41-0
• Poids moléculaire : 344.88 (free base basis)
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Chaîne SMILES: ClC(C=C1)=CC2=C1OC3=C(N2CCCCN(CC)CC)C=CC=C3
• InChI: 1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H
• Clé InChI: SVKSJUIYYCQZEC-UHFFFAOYSA-N

Description

Description générale

A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 M) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 M), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2, the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. The solid form of this compound is also available.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Akt

Reversible: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Forme physique

A 20 mM (2 mg/262 µL) solution of Akt Inhibitor X (Cat. No. 124020) in H₂O.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Autres remarques

Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA107, 16982.
Thimmaiah, K.N., et al. 2005. J. Biol. Chem.280, 31924.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable