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Merck
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Key Documents

918652

Sigma-Aldrich

Low endotoxin alginate solution

Medium viscosity, 0.2 μm, sterile-filtered

Synonyme(s) :

Alginic acid, Sodium alginate

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About This Item

Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Niveau de qualité

100

Stérilité

sterile-filtered

Forme

viscous liquid

Concentration

1.75-3.50 wt. % in DPBS (buffer)

Impuretés

<10 EU/g Endotoxin
<5 CFU/g Bioburden (Fungal)
<5 CFU/g Bioburden (Total Aerobic)

Couleur

colorless to pale yellow

Taille des particules

0.2 μm

pH

6.5-7.5

Température de stockage

2-8°C

Application

Low endotoxin alginate solution is a 2 % low endotoxin alginate solution in DPBS buffer. It is sterile filtrated through 0.2 μm sterile filter, and ready to be used in biomedical applications.
Alginate is an anionic polysaccharide that is widely used in pharmaceutical and biomedical applications due to its non-animal origin, low toxicity, biocompatibility, and biodegradability. Alginate hydrogels are commonly used to fabricate tissue engineering scaffolds, bioinks for 3D bioprinting, and nanocarriers for drug & gene delivery. Alginate is commonly crosslinked into a hydrogel via ionic-crosslinking with divalent cations (e.g., Ca2+).

Conditionnement

10 mL in glass bottle

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

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Jia Jia et al.
Acta biomaterialia, 10(10), 4323-4331 (2014-07-08)
Recent advances in three-dimensional (3-D) printing offer an excellent opportunity to address critical challenges faced by current tissue engineering approaches. Alginate hydrogels have been used extensively as bioinks for 3-D bioprinting. However, most previous research has focused on native alginates
Eneko Axpe et al.
International journal of molecular sciences, 17(12) (2016-11-30)
Three-dimensional (3D) bioprinting is on the cusp of permitting the direct fabrication of artificial living tissue. Multicellular building blocks (bioinks) are dispensed layer by layer and scaled for the target construct. However, only a few materials are able to fulfill
Kuen Yong Lee et al.
Progress in polymer science, 37(1), 106-126 (2011-11-30)
Alginate is a biomaterial that has found numerous applications in biomedical science and engineering due to its favorable properties, including biocompatibility and ease of gelation. Alginate hydrogels have been particularly attractive in wound healing, drug delivery, and tissue engineering applications
Tarun Agarwal et al.
ACS applied materials & interfaces, 8(47), 32132-32145 (2016-12-10)
Success of bone tissue engineering (BTE) relies on the osteogenic microarchitecture of the biopolymeric scaffold and appropriate spatiotemporal distribution of therapeutic molecules (growth factors and drugs) inside it. However, the existing technologies have failed to address both the issues together.

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