230715

n-Butyllithium solution

11.0 M in hexanes

• Synonyme(s) : n-BuLi, Butyl lithium, Butyllithium solution, Lithium-1-butanide
• Formule linéaire : CH₃(CH₂)₃Li
• Numéro CAS: 109-72-8
• Poids moléculaire : 64.06
• Numéro Beilstein : 1209227
• Numéro MDL: MFCD00009414
• Code UNSPSC : 12352103
• ID de substance PubChem : 24853833
• Nomenclature NACRES : NA.22

Propriétés

• Forme: liquid
• Niveau de qualité: 100
• Concentration: 11.0 M in hexanes
• Densité: 0.761 g/mL at 25 °C
• Température de stockage: 2-8°C
• Chaîne SMILES: [Li]CCCC
• InChI: 1S/C4H9.Li/c1-3-4-2;/h1,3-4H2,2H3;
• Clé InChI: MZRVEZGGRBJDDB-UHFFFAOYSA-N

Description

Description générale

n-Butyllithium (n-BuLi) is an organolithium reagent commonly used as a strong base to form corresponding lithium salts by the deprotonation of nitrogen, oxygen, phosphorus, and carbon acids. Heterocyclic compounds, such as furans, thiophenes, oxazoles, pyrroles, etc, can be lithiated α to the ring heteroatom using n?BuLi. These lithiated salts reacting in situ with alkyl halides to obtain useful organic compounds by the formation of the C-C bond.

Application

n-BuLi can be used as a reagent for lithium-halogen exchange reactions. Synthesis of various other useful reagents such as lithium diisopropylamide (LDA) and diphenylphosphine is prepared by in situ reaction with n-BuLi . In the polymerization of dienes, it can be employed as an initiator.

Conditionnement

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Informations légales

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Informations sur la sécurité

• Pictogrammes: GHS02,GHS08,GHS05,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H225,H250,H260,H304,H314,H336,H361f,H372,H411
• Conseils de prudence: P210 - P231 + P232 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P370 + P378
• Classification des risques: Aquatic Chronic 2 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Pyr. Liq. 1 - Repr. 2 - Skin Corr. 1B - STOT RE 1 Inhalation - STOT SE 3 - Water-react 1
• Organes cibles: Central nervous system, Nervous system
• Risques supp: EUH014
• Code de la classe de stockage: 4.2 - Pyrophoric and self-heating hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): -7.6 °F - closed cup
• Point d'éclair (°C): -22 °C - closed cup
• Équipement de protection individuelle: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter