G8035
Anti-Glial Cell-derived Neurotrophic Factor (GDNF) antibody produced in goat
IgG fraction of antiserum, lyophilized powder
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About This Item
Produits recommandés
Source biologique
goat
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
IgG fraction of antiserum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
lyophilized powder
Espèces réactives
human
Technique(s)
neutralization: suitable
Numéro d'accès UniProt
Température de stockage
−20°C
Informations sur le gène
human ... GDNF(2668)
Description générale
The antibody neutralizes the biological activity of recombinant human GDNF.
Immunogène
recombinant human GDNF expressed in Escherichia coli.
Actions biochimiques/physiologiques
Glial cell-derived neurotrophic factor is a potent neurotrophic factor that is important for the maintenance, regeneration and survival of specific neuronal cells including autonomic neurons, motoneurons, noradrenergic and seotonergic neurons. Additionally, it promotes the invasion and metastatic behavior of certain types of cancers by activating ERK, p38, JNK and AP-1 mediated cell signaling.
Forme physique
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline
Notes préparatoires
Purified using protein G.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Shelley J Allen et al.
Pharmacology & therapeutics, 138(2), 155-175 (2013-01-26)
Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival, maintenance and regeneration of specific neuronal populations in the adult brain. Depletion of these neurotrophic factors has been
Jing-Yuan Chuang et al.
Oral oncology, 49(12), 1103-1112 (2013-09-28)
Perineural invasion is a prominent clinical feature of various cancers, which causes difficulty in curative resection. Glial cell-derived neurotrophic factor (GDNF), a potent neurotrophic factor, plays an important role in the invasive and metastatic behavior of various cancers. The aim
Mikko Airavaara et al.
Parkinsonism & related disorders, 18 Suppl 1, S143-S146 (2011-12-23)
Although initially thought to be important primarily in neural development, a number of trophic proteins have been found to have neuroprotective and neuroregenerative activity in the adult central nervous system, particularly for midbrain dopamine neurons (MDN). Neurorestoration is potentially feasible
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