D4505

5,5-Diphenylhydantoin sodium salt

≥99%

• Synonyme(s) : 5,5-Diphenyl-2,4-imidazolidinedione, Phenytoin
• Formule linéaire : C₁₅H₁₁N₂O₂Na
• Numéro CAS: 630-93-3
• Poids moléculaire : 274.25
• Numéro CE : 211-148-2
• Numéro MDL: MFCD00069674
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277707
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥99%
• Forme: powder
• Solubilité: aqueous base: soluble
• Chaîne SMILES: [Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
• InChI: 1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
• Clé InChI: FJPYVLNWWICYDW-UHFFFAOYSA-M
• Informations sur le gène: human ... CNR1(1268) , CNR2(1269) , CYP2C9(1559) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Faah(29347) , Scn1a(81574) , Scnn1g(24768) , Slc6a1(79212)

Description

Description générale

5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin.[1] 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors.[2] Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.[3]

Application

5,5-Diphenylhydantoin sodium salt has been used:

• in the cream preparation for treating burn wounds[4]
• in seizure behavior testing as an anticonvulsant in Drosophila[5]
• in in vivo embryo toxicity test in mouse embryonic stem cells[6]

Actions biochimiques/physiologiques

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na⁺, K⁺, and Ca²⁺ channels.

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes.

Caractéristiques et avantages

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Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H317,H361
• Conseils de prudence: P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges