C4024

Carbamazepine

≥98% (HPLC), powder, sodium channel inhibitor

• Synonyme(s) : 5H-Dibenz[b,f]azepine-5-carboxamide
• Formule empirique (notation de Hill) : C₁₅H₁₂N₂O
• Numéro CAS: 298-46-4
• Poids moléculaire : 236.27
• UNSPSC Code: 12352200
• eCl@ss: 34051404
• PubChem Substance ID: 57654002
• NACRES: NA.77
• EC Number: 206-062-7
• MDL number: MFCD00005073
• Form: powder

Propriétés

• Nom du produit: Carbamazepine, powder
• form: powder
• Quality Segment: 100
• mp: 191-192 °C (lit.)
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 29 mg/mL, H₂O: insoluble, ethanol: soluble, propylene glycol: soluble
• originator: Novartis
• storage temp.: 2-8°C
• SMILES string: NC(=O)N1c2ccccc2C=Cc3ccccc13
• InChI: 1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
• InChI key: FFGPTBGBLSHEPO-UHFFFAOYSA-N
• Gene Information: human ... BZRAP1(9256), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), PRNP(5621), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335) ; rat ... Scn2a1(24766), Scnn1a(25122), Scnn1g(24768), Slc6a1(79212)

Description

Application

Carbamazepine has been used to investigate its behavior in wastewater treatment and during groundwater infiltration. It has also been used to find out its effects on spontaneous seizures in rats.

Biochem/physiol Actions

Carbamazepine is considered as a safe antiepileptic drug. It decreases the multiple drug therapy and maintains a better control of epilepsy.

Anticonvulsant; ligand for the GABA_A receptor benzodiazepine modulatory site. Sodium channel inhibitor.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mot-clé: Danger
• Codes de danger: H302,H317,H334,H336,H360FD
• Mentions de précaution: P202 - P261 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1A - Resp. Sens. 1 - Skin Sens. 1A - STOT SE 3
• Organes cibles: Central nervous system
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Que se passe-t-il ?: WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): dust mask type N95 (US), Eyeshields, Faceshields, Gloves