A8404

Amitriptyline hydrochloride

≥98% (TLC), norepinephrine and serotonin transporter inhibitor, powder

• Formule empirique (notation de Hill) : C₂₀H₂₃N · HCl
• Numéro CAS: 549-18-8
• Poids moléculaire : 313.86
• NACRES: NA.77
• PubChem Substance ID: 24278073
• UNSPSC Code: 12352200
• EC Number: 208-964-6
• MDL number: MFCD00012537
• Assay: ≥98% (TLC)
• Form: powder

Propriétés

• Nom du produit: Amitriptyline hydrochloride, ≥98% (TLC), powder
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• color: white to off-white
• solubility: H₂O: soluble, ethanol: soluble
• originator: Bristol-Myers Squibb
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
• InChI key: KFYRPLNVJVHZGT-UHFFFAOYSA-N
• Gene Information: human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), SLC6A2(6530), SLC6A4(6532)

Description

Application

Amitriptyline hydrochloride has been used:

• as an antidepressant to study its effects on social behavior and memory in transgenic for acid sphingomyelinase (t-ASM) mice
• as a tricyclic antidepressant to analyze its effects on glucocorticoid receptor function in whole human blood
• as an anti-depressant to study its effects on scratching and locomotion behavior in chloroquine-induced mouse

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Tricyclic antidepressant; norepinephrine and serotonin transporter inhibitor; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Amitriptyline hydrochloride shows therapeutic effects against anxiety, maniac depression, and involutional melancholia. It possesses antihistaminic, anticholinergic, and antiserotonimic properties. Amitriptyline hydrochloride acts as an amphiphilic agent and exhibits neuroleptic activity.

Features and Benefits

Shelf-life of the powder is at least three years.

Informations sur la sécurité

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H301,H319,H361d,H410
• pcodes: P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges